Scientists at Nagoya University, with colleagues at Kyoto University in Japan, have uncovered a mechanism that allows a protein complex to bind to DNA without impeding some of the important processes of cell division. Their ...
Cell & Microbiology
Jun 22, 2021
0
9
Of all the proteins of the SARS-CoV-2 virus (the pathogen that causes COVID-19), the spike protein is the one that gets the most attention. This attention is well-deserved—the spike protein is essential for latching on ...
Cell & Microbiology
Jun 17, 2021
0
203
For all animals, eliminating some cells is a necessary part of embryonic development. Living cells are also naturally sloughed off in mature tissues; for example, the lining of the intestine turns over every few days.
Cell & Microbiology
May 5, 2021
0
114
Over the last 60 years, scientists have been able to observe how and when genetic information was replicated, determining the existence a "replication timing program," a process that controls when and in what order segments ...
Molecular & Computational biology
Apr 23, 2021
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1241
In preparation for cell division, cells need to replicate the DNA that they contain. A team of researchers from TU Delft, collaborating with investigators from the Francis Crick Institute in London, has now shown that the ...
Cell & Microbiology
Mar 30, 2021
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167
Cold Spring Harbor Laboratory (CSHL) President and CEO Bruce Stillman has been dissecting DNA replication, a critical step in cell division, since the 1980s. His lab studies how Origin Recognition Complexes—ORCs—coordinate ...
Molecular & Computational biology
Mar 23, 2021
0
189
A study that identifies how a coronavirus protein called Nsp1 blocks the activity of genes that promote viral replication provides hope for new COVID-19 treatments.
Molecular & Computational biology
Feb 16, 2021
0
28
Researchers from the Hong Kong University of Science and Technology (HKSUST) and the University of Hong Kong (HKU) recently demonstrated that the selectivity determinant of Origin Recognition Complex (ORC) for DNA binding ...
Cell & Microbiology
Jan 27, 2021
0
57
A chemical probe molecule—a "first gen" molecule that can be used for drug development—that targets a host cell's protein quality control pathways can dramatically reduce infection by Dengue and Zika viruses. The research ...
Cell & Microbiology
Jan 27, 2021
0
35
Many proteins are required to maintain the structure, and to preserve the genetic integrity, of DNA. Sliding clamps are proteins that increase the efficiency of DNA replication. Without these proteins, cells would not be ...
Molecular & Computational biology
Dec 10, 2020
0
86
