Embryo's early development revealed in a dish

During embryonic development, the entire nervous system, the skin and the sensory organs emerge from a single sheet of cells known as the ectoderm. While there have been extensive studies of how this sheet forms all these ...

A 'rheostat' for cancer signals

WNT signaling pathways play important roles in cell growth, development and cancer. The classical or "canonical" WNT pathway and its atypical, "non-canonical" counterpart share a protein called DVL2 that "transduces" or converts ...

Mitochondrial unfolded protein response signals imminent danger

Misfolded proteins must be promptly eliminated as they can form toxic aggregates in cells. LMU biologists have studied how this process is triggered in mitochondria and identified a general alarm signal that activates it.

A new signaling pathway for mTor-dependent cell growth

The activation of mTor complex 1 in the cell is central to many vital processes in the body such as cell growth and metabolism. Overactivity of this signaling pathway can result in diseases such as in diabetic insulin resistance ...

Breath! Respiring microbes generate more energy

How do cells generate and use energy? This question might seem simple, but the answer is far from simple. Furthermore, knowing how microbial cell factories consume energy and how proteins are allocated to do so is crucial ...

Control theory: Mother nature is an engineer

In the last 150 years, engineers have developed and mastered ways to stabilize dynamic systems, without lag or overshoot, using what's known as control theory. Now, a team of University of Arizona researchers has shown that ...

Detox pathway extends lifespan of the worm C. elegans

A mutant worm with a change in one mitochondrial gene produces more reactive oxygen species (ROS), which can be harmful to cells by causing oxidative stress. However, this mutant worm is able to live twice as long as the ...

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