New insights into centromere structure

Researchers led by Osaka University used cryogenic electron microscopy to analyze the atomic structure of the centromeric region of the chromosome, essential for cell division. A protein called CENP-A marks the centromere; ...

Enzyme 'atlas' helps researchers decipher cellular pathways

One of the most important classes of human enzymes are protein kinases—signaling molecules that regulate nearly all cellular activities, including growth, cell division, and metabolism. Dysfunction in these cellular pathways ...

Some cancer cells may not be as immortal as previously thought

Scientists at Johannes Gutenberg University Mainz (JGU) and the Institute of Molecular Biology (IMB) in Mainz may have discovered new insights into how cancer cells regulate the ends of their chromosomes, called telomeres. ...

Newly discovered process brings immune cells up to speed

Cancer cells use an unusual mechanism to migrate into new tissue and form metastases there. The same process probably also keeps some immune cells on their toes. This is the result of a recent study led by the University ...

'Mystery gene' matures the skeleton of the cell

"I'm a professional pin-in-a-haystack seeker," geneticist Thijn Brummelkamp responds when asked why he excels at tracking down proteins and genes that other people did not find, despite the fact that some have managed to ...

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