The path from stem cell to maturity

Regulation of gene expression is essential to make sure cell maturation occurs as it should. European research is taking an integrated perspective on how selected steps in liver and blood cell differentiation can be modulated.

Regulating hematopoietic differentiation

Blood cells originate from a small pool of hematopoietic stem cells (HSCs) through a complex process of differentiation steps that are tightly regulated at the transcriptional level. Dissecting the mechanisms underlying this ...

Clarifying the mechanism for making blood cells

In 1917, Florence Sabin, the first female member of the US National Academy of Sciences, discovered hemangioblasts, the common precursor cells for blood cells and blood vessel endothelia. Her discovery faced a great deal ...

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