An understanding of particle diffusion in the presence of constrictions is essential in fields as diverse as drug delivery, cellular biology, nanotechnology, materials engineering, and spread of pollutants in the soil. When ...
General Physics
Jun 16, 2010
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In nature, evolution takes place over eons: A slow accumulation of adaptations gradually produces new traits and species. But evolution can also happen on a small and fast scale in the laboratory.
Biotechnology
May 13, 2010
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Studies led by Stony Brook University professor of chemistry Peter J. Tonge indicate that modifications that enhance the time a drug remains bound to its target, or residence time, may lead to better diagnostic and therapeutic ...
Biochemistry
Apr 25, 2010
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Proteins, which perform such vital roles in our bodies as building and maintaining tissues and regulating cellular processes, are a finicky lot. In order to work properly, they must be folded just so, yet many proteins readily ...
Cell & Microbiology
Dec 10, 2009
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Using an unconventional approach that they designed, University of Pittsburgh drug discoverers and their collaborators at Walter Reed Army Institute of Research have identified compounds that hold promise for treating leishmaniasis, ...
Biochemistry
Nov 3, 2009
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While studying an HIV protein that plays an essential role in AIDS progression, researchers at the University of Pittsburgh School of Medicine have discovered compounds that show promise as novel treatments for the disease.
Biochemistry
Oct 13, 2009
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Until now, the mode of action of nitrogen-containing bisphosphonate (N-BP) cancer drugs, used to relieve bone pain and to prevent skeletal complications in bone metastasis, has been almost entirely unknown. Researchers writing ...
Biotechnology
Sep 9, 2009
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Whitehead Institute scientists have developed a rapid, inexpensive drug-screening method that could be used to target diseases that until now have stymied drug developers, such as Parkinson's disease. This technique uses ...
Biochemistry
Jul 13, 2009
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Scientists at Burnham Institute for Medical Research (Burnham) have discovered that specific microRNAs (non-coding RNAs that interfere with gene expression) reduce HIV replication and infectivity in human T-cells. In particular, ...
Biochemistry
Jun 25, 2009
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RUDN University chemists have synthesized new isoquinoline derivatives. Due to their biological activity, these compounds have applications in new drugs, including antispasmodics and bactericidal agents. Additionally, in ...
Materials Science
Nov 15, 2017
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