Sigma receptors are proteins found mainly on the surface of endoplasmic reticulum (ER) in certain cells. Sigma-1 and sigma-2 are the two main classes of these receptors. The sigma-1 receptor is involved in neurological disorders ...
Biochemistry
Jun 19, 2019
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Chemists at Tokyo Tech's Laboratory for Chemistry and Life Science have designed and developed a capsule-shaped synthetic receptor that can distinguish between male and female steroid hormones. Namely, the receptor displays ...
Biochemistry
Apr 22, 2019
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A team of researchers at Ehime University revealed the binding affinities of perfluoroalkyl substances (PFASs) to Baikal seal peroxisome proliferator-activated receptor α (PPARα) using in vitro and in silico approaches. ...
Environment
Mar 28, 2019
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Solutions to many real-world scientific and engineering problems—from improving weather models and designing new energy materials to understanding how the universe formed—require applications that can scale to a very ...
Software
Aug 01, 2018
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Fujitsu Laboratories today announced the development of molecular simulation technology for drug discovery that can accurately estimate binding affinity, which represents the degree to which proteins that can cause diseases ...
Biochemistry
May 07, 2018
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Peptides are short chains of amino acids that can bind to proteins and change their function. They show high binding affinity, low toxicity, and are easy to synthesize, all of which makes peptides ideal for use in drug development, ...
Biochemistry
Apr 30, 2018
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A joint industry/academia study of a cancer target protein reveals unusual relation between binding site flexibility and drug-target lifetime. The results, published in Nature Communications, suggest a new strategy for drug ...
Biochemistry
Jan 15, 2018
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Scientists from the Center for Self-assembly and Complexity (CSC) successfully isolated a cancer-prone protein by fishing out the proteins using 'molecular bait'. Cancer, according to the American Cancer Society, affects ...
Biochemistry
Mar 02, 2017
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An artificial base that enhances the protein-binding affinity and selectivity of DNA expands the DNA machinery.DNA aptamers are expected to play an important role in the diagnosis and treatment of various cancers and other ...
Biochemistry
Jul 19, 2013
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With mutations, it turns out that context can be everything in determining whether or not they are beneficial to their evolutionary fate.
Evolution
Jun 13, 2013
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