Gene therapy using CRISPR/Cas9 gene editing is currently in clinical trials around the world for a variety of diseases. A report from Boston Children's Hospital, published June 27 in Nature Communications, warns of a potential, ...
Cell & Microbiology
Jul 6, 2022
1
219
Within a mere eight years, CRISPR-Cas9 has become the go-to genome editor for both basic research and gene therapy. But CRISPR-Cas9 also has spawned other potentially powerful DNA manipulation tools that could help fix genetic ...
Biotechnology
Jul 30, 2020
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425
A team from the Broad Institute of MIT and Harvard has developed a new CRISPR genome-editing approach by combining two of the most important proteins in molecular biology—CRISPR-Cas9 and a reverse transcriptase—into a ...
Biotechnology
Oct 21, 2019
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339
Using a technique that can precisely edit DNA bases, MIT researchers have created a way to store complex "memories" in the DNA of living cells, including human cells.
Biotechnology
Aug 22, 2019
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317
A Massachusetts General Hospital (MGH) research team reports that several of the recently developed CRISPR base editors, which create targeted changes in a single DNA base, can induce widespread off-target effects in RNA, ...
Biotechnology
Apr 17, 2019
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189
An international team of researchers has succeeded in making 13,200 edits to a single cell—and the cell survived. In their paper uploaded to the bioRxiv preprint server, the team describes the edits they made, how they ...
A research team from the LKS Faculty of Medicine, the University of Hong Kong (HKUMed) has developed a new way to break through the current limited throughput in optimizing precise genome editors at scale, and engineer hundreds ...
Biotechnology
Jun 29, 2023
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58
Gao Caixia's group from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences has pioneered the use of artificial intelligence (AI)-assisted methods to discover novel deaminase proteins with ...
Biotechnology
Jun 27, 2023
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16
Gao Caixia's group from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences (CAS) has developed a new method of downregulating gene translation to a predictable and desired level in plants ...
Biotechnology
Mar 9, 2023
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9
A new tool to predict the chances of successfully inserting a gene-edited sequence of DNA into the genome of a cell, using a technique known as prime editing, has been developed by researchers at the Wellcome Sanger Institute. ...
Biotechnology
Feb 16, 2023
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17
