Are bacteriophages the new antibiotics?

Bacteriophages, viruses that infect bacteria, may be used as an alternative treatment option when antibiotics fail. Leiden researchers have studied the structure and function of a novel bacteriophage that could be used to ...

How bacteriophage resistance shapes Salmonella populations

Researchers from the Quadram Institute and the University of East Anglia have uncovered how resistance has helped drive the emergence of dominant strains of Salmonella. In addition to antimicrobial resistance, resistance ...

Scientists discover new antiviral defense system in bacteria

Bacteria use a variety of defense strategies to fight off viral infection, and some of these systems have led to groundbreaking technologies, such as CRISPR-based gene-editing. Scientists predict there are many more antiviral ...

Viruses help combat antibiotic-resistant bacteria

More and more bacteria are becoming resistant to antibiotics. Bacteriophages are one alternative in the fight against bacteria. These viruses attack very particular bacteria in a highly specific way. Now a Munich research ...

How bacteria evade bacteriophages in vivo

Phage therapy, which uses viruses known as bacteriophages to treat bacterial infections, is a long-standing medical procedure whose mechanisms of action are still poorly understood. Scientists from the Institut Pasteur and ...

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Bacteriophage

A bacteriophage (from 'bacteria' and Greek φαγεῖν phagein "to devour") is any one of a number of viruses that infect bacteria. They do this by injecting genetic material, which they carry enclosed in an outer protein capsid. The genetic material can be ssRNA, dsRNA, ssDNA, or dsDNA ('ss-' or 'ds-' prefix denotes single-strand or double-strand) along with either circular or linear arrangement.

Bacteriophages are among the most common and diverse entities in the biosphere. The term is commonly used in its shortened form, phage.

Phages are widely distributed in locations populated by bacterial hosts, such as soil or the intestines of animals. One of the densest natural sources for phages and other viruses is sea water, where up to 9×108 virions per milliliter have been found in microbial mats at the surface, and up to 70% of marine bacteria may be infected by phages. They have been used for over 90 years as an alternative to antibiotics in the former Soviet Union and Eastern Europe as well in France. They are seen as a possible therapy against multi-drug-resistant strains of many bacteria.

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