The gene code of growing limbs

When a fetus develops, cell division and differentiation, gene expression, cell-to-cell signaling, and morphogenesis must be carefully coordinated to occur in the correct sequence and for the proper amount of time. Failures ...

Evolution: The genetic connivances of digits and genitals

During the development of mammals, the growth and organization of digits are orchestrated by Hox genes, which are activated very early in precise regions of the embryo. These "architect genes" are themselves regulated by ...

The swing of architect genes

Architect genes are responsible for organizing structures of the body during embryonic development. Some of them, namely the Hox genes, are involved in the formation of forelimbs. They are activated in two successive waves, ...