Pateamine A (PatA), a natural product first isolated from marine sponges, has attracted considerable attention as a potential anti-cancer agent, and now a new activity has been found for it, which may reveal yet another anti-cancer ...
Biochemistry
Nov 2, 2009
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0
Much like shoelaces or dangly necklaces, DNA strands can tangle up in unruly knots. Specialized enzymes keep DNA organized when cells divide, so the cells split smoothly and don't get stuck. But in tumor cells, this failsafe ...
Biochemistry
Feb 5, 2019
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8
A group of researchers at the University of California, Berkeley have for the first time described the structure of the active site core of topoisomerase II alpha, an important target for anti-cancer drugs.
Cell & Microbiology
Nov 15, 2012
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0
Many important medicines, such as antibiotics and anticancer drugs, are derived from natural products of bacteria. The enzyme complexes that produce these active ingredients have a modular design that makes them ideal tools ...
Cell & Microbiology
Mar 21, 2024
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51
Scientists at Tufts University School of Medicine have developed a genome-scale metabolic model or "subway map" of key metabolic activities of the bacterium that causes Lyme disease. Using this map, they have successfully ...
Cell & Microbiology
Oct 19, 2023
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8
Could there be a way to chemically manipulate small, confined areas on cellular surfaces? Scientists have developed a microfluidic probe to send a flow of free radicals on live cells and track the outcome using fluorescence ...
Biochemistry
Apr 6, 2021
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126
Most chemistry students are well aware of the anticancer properties of cisplatin, cis-Pt(NH3)2Cl2, as a result of the pioneering work of Professor Barnett Rosenberg and his colleagues at the Michigan State University in ...
Biochemistry
Nov 24, 2016
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5
New research could pave the way to developing cancer drugs targeting an enzyme that inhibits ferroptosis, a type of cell death. Cancer cells that are resistant to anticancer drugs are known to be vulnerable to ferroptosis. ...
Biotechnology
Apr 5, 2024
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50
DNA is small. Really, really, small. So, when researchers want to study the structure of a single-stranded DNA, they can't just pull out their microscopes: they have to get creative.
Biotechnology
Mar 7, 2019
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6
As part of their efforts to devise ways to minimize the side effects of drugs for treating cancer, four RIKEN chemists have found a biocompatible way to convert compounds with low biological activity into anticancer drugs ...
Materials Science
May 18, 2021
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