A major discovery is challenging accepted thinking about amyloids - the fibrous protein deposits associated with diseases such as Alzheimer's and Parkinson's - and may open up a potential new area for therapeutics.
Biochemistry
Dec 4, 2009
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More than half of all cases of dementia in the elderly can be attributed to Alzheimer's disease. Despite vast research efforts, an effective therapy has not been developed, and treatment consists of dealing with the symptoms. ...
Biochemistry
Jan 12, 2012
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An international team of researchers have discovered a new type of transition in protein folding: amyloid crystals formed from amyloid fibrils by a decrease in energy. The crystals are even more stable than the fibrils, which ...
Biochemistry
Nov 7, 2017
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The century old mission to understand how the proteins responsible for amyloid-based diseases such as Alzheimer's, Huntingdon's and Parkinson's work has taken major steps forward in the last 12 months, thanks to a revolution ...
Biochemistry
Oct 30, 2018
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Scientists at UC Santa Barbara and several other institutions have found laboratory evidence that a cluster of peptides may be the toxic agent in Alzheimer's disease. Scientists say the discovery may lead to new drugs for ...
Biochemistry
Jul 1, 2009
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A team of researchers from Durham University in the U.K. and Shaanxi Normal University in China has discovered a type of protein that forms naturally into two main types of helical braids. In their paper published in the ...
Scientists at The Scripps Research Institute (TSRI) have discovered a way to decrease deadly protein deposits in the heart, kidney and other organs associated with a group of human diseases called the systemic amyloid diseases.
Cell & Microbiology
Oct 23, 2014
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A team at UT Southwestern has developed a computational approach to uncover mechanisms of protein misfolding linked to neurodegenerative diseases. The study, published in Nature Communications, offers key insights that could ...
Biochemistry
Mar 27, 2023
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Swiss researchers have developed a new approach to measure proteins with structures that change. This could enable new diagnostic tools for the early recognition of neurodegenerative diseases to be developed.
Biotechnology
Sep 14, 2014
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A metallic molecule being studied at Rice University begins to glow when bound to amyloid protein fibrils of the sort implicated in Alzheimer's disease. When triggered with ultraviolet light, the molecule glows much brighter, ...
Biochemistry
Jul 7, 2016
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