Related topics: brain

How damaging proteins form

Alzheimer's disease and Parkinson's disease are both examples of amyloid diseases, where malfunctioning proteins accumulate to form fibrils and larger aggregates called amyloid plaques. In the journal Biophysical Chemistry ...

A chemical tailor-made suit for Alzheimer's drugs

With over 1.2 million people affected in Germany alone and over 50 million people worldwide, Alzheimer's disease, also referred to simply as Alzheimer's, is one of the greatest medical and social challenges of our time. Due ...

Templating S100A9 amyloids on Aβ fibrillar surfaces revealed

A research team lead by Ludmilla Morozova Roche at Umeå University, Sweden, has provided the mechanistic insight into protein co-aggregation in Alzheimer's disease. The templating mechanism of S100A9 amyloids on Aβ fibrillar ...

Gold nanoparticles uncover amyloid fibrils

EPFL scientists have developed powerful tools to unmask the diversity of amyloid fibrils, which are associated with Alzheimer's disease and other neurodegenerative disorders. The scientists made the breakthrough by developing ...

A boundary dance of amyloid-β stepping into dementia

Alzheimer's disease is caused by aggregates of amyloid-β (Aβ) peptides. This aggregation is accelerated at the cell membrane surface. Using molecular dynamics simulations and NMR experiments, the research group at ExCELLS ...

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