Scientists at the Friedrich Miescher Institute for Biomedical Research have identified a novel and unexpected regulatory activity of RNA at the edge of inactive chromosomal regions. In their publication in Nature Structural ...
Cell & Microbiology
Aug 8, 2013
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In exploring how proteins interact with crucial DNA sequences to regulate gene activity, researchers have shed light on key biological events that may eventually be manipulated to provide new disease treatments.
Cell & Microbiology
Jun 7, 2012
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Cells use RNA as a versatile tool to regulate the activity of their genes. Small snippets of RNA can fine-tune how much protein is produced from various genes; some small RNAs can shut genes off altogether. An enzyme called ...
Cell & Microbiology
Mar 17, 2022
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A single embryonic stem cell can develop into more than 200 specialized cell types that make up our body. This maturation process is called differentiation and is tightly regulated. If the regulation is lost, specialized ...
Cell & Microbiology
Feb 7, 2013
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Using a complex modeling program that helps analyze the physical dynamics of large, structurally complex protein molecules, a research team has made progress towards finding a weak spot in the architecture of a group of enzymes ...
Biochemistry
May 28, 2015
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A revolutionary new protein stabilisation technique has been developed by scientists funded by the Biotechnology and Biological Sciences Research Council which could lead to 30 per cent more proteins being available as potential ...
Bio & Medicine
Jun 25, 2009
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An international research team has for the first time obtained the structure of the light-sensitive sodium-pumping KR2 protein in its active state. The discovery provides a description of the mechanism behind the light-driven ...
Cell & Microbiology
May 28, 2020
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51
Many plant and animal pathogens deploy effector proteins as part of their 'molecular arsenal' to facilitate infection and colonisation of their hosts. New research has revealed the structure of a bacterial effector molecule ...
Cell & Microbiology
Jun 11, 2012
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Cancer occurs when human cells move and multiply inappropriately. Within cells, a process called phosphorylation serves as an on/off switch for a number of cellular processes that can be involved in cancer, including metabolism, ...
Biotechnology
Jun 27, 2010
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Enzymes called protein kinases modulate cellular activities in virtually every organism. They switch other proteins off or on by tacking on phosphate chemical groups—a process known as phosphorylation—to regulate the ...
Cell & Microbiology
Aug 2, 2013
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