In recent years, scientists have developed methods to measure a cell's transcriptome, or all the RNA produced by a cell, to study the cell's identity and genetic activity. However, these methods rely on killing the cell to ...
RNA-based therapeutics use RNA as a blueprint that enables cells to produce specific proteins—including proteins that can precisely modify genes. For this to work, the RNA must reach the inside of the cell intact. Delivery ...
Targeted drug delivery directly to the liver has unlocked major breakthroughs across medicine, but constructing the chemical key to enter liver cells remains complex and costly. Today, researchers at Kumamoto University, ...
A research team from The Hong Kong University of Science and Technology (HKUST) has developed an innovative "one-pot" testing platform, known as TEMPO, that could transform highly sensitive nucleic acid testing from a laboratory-based ...
The ability to precisely adjust the expression of genes inside the human body—ramping up protective ones and tamping down harmful ones—holds enormous potential for treating and preventing disease. But the standard molecular ...
When a cell gets ready to divide, it shuts down its gene-reading machinery almost entirely. For decades, the mechanism behind that shutdown was only partially understood. A new study co-led by Alarcón and Lilian Kabeche, ...
Researchers at the University of Cincinnati have identified a potential new target to prevent the spread of Chagas disease. The parasitic infection is transmitted through the bite of the kissing bug in Central and South America ...
The adult human brain has limited capacity to repair or regenerate neurons lost to Alzheimer's disease, the most common type of dementia. Existing treatments can slow disease progression but do not reverse cognitive decline. ...
Scientists at the Department of Energy (DOE)'s Oak Ridge National Laboratory (ORNL) have shown that more than 93% of possible E. coli CRISPR-Cas9 guide RNAs—molecules that direct the gene-editing CRISPR tool to the right ...
Weill Cornell Medicine investigators have developed a set of molecular tools to regulate the activity of specific genes in one of the most common classes of intestinal bacteria. The ability to genetically manipulate these ...
