See also stories tagged with Drug discovery
Like a delivery driver navigating crowded city streets, a gene-therapy-toting lipid nanoparticle faces a gauntlet of potential detours on its journey toward a cell's nucleus. First, there's entering the cell's plasma membrane; ...
Designing an effective antibody drug is like searching for the right key in a warehouse of locks. Scientists may begin with millions—or even billions—of antibody candidates, but only a tiny fraction will recognize and bind ...
Long before humans discovered biodegradable plastics, microorganisms had already invented their own. Many bacteria and archaea produce natural bioplastics called polyhydroxyalkanoates (PHAs), storing them inside their cells ...
Researchers at the University of Wisconsin–Madison have developed a simpler way to produce a fast-growing class of targeted cancer therapies, a discovery that could make the medicines easier to manufacture consistently while ...
More than 100,000 people are awaiting an organ transplant in the United States, with a new candidate added to the list every 10 minutes. Even if the transplant is carried out successfully, recipients must take immunosuppressive ...
The decades-old scientific quest to create brand-new proteins has been turbocharged in the era of artificial intelligence.
Scientists have long been fascinated by two promising classes of antibiotics that disable RNA polymerase (RNAP). They knew that these drugs could grind gene expression to a halt in several pathogens, including the bacterium ...
Every living cell, from the simplest bacterium to a human neuron, relies on the same basic machinery to read, interpret, and use its DNA. This molecular machinery is so fundamental that life as we know it cannot exist without ...
For most healthy people, Cryptococcus is an unnoticed infection. The immune system walls it off in the lungs and keeps it dormant for life. But in patients undergoing cancer chemotherapy, recovering from an organ transplant, ...
In a world first, scientists led by a team from Stanford University have created 16 viable viruses that do not exist in nature and were designed by AI. Their experiment, which is published in Science, could help in the fight ...
