Search results for CRISPR

Biotechnology Nov 7, 2024

RNA-targeting CRISPR reveals that hundreds of noncoding RNAs are essential—not 'junk'

Genes contain instructions for making proteins, and a central dogma of biology is that this information flows from DNA to RNA to proteins. But only two percent of the human genome actually encodes proteins; the function of ...

Biotechnology Nov 6, 2024

Genetic repair via CRISPR can inadvertently introduce other defects, researchers show

The CRISPR molecular scissors have the potential to revolutionize the treatment of genetic diseases. This is because they can be used to correct specific defective sections of the genome. Unfortunately, however, there is ...

Cell & Microbiology Nov 4, 2024

Newly described anti-viral defense system in bacteria aborts infection by chemically altering mRNA

Like humans and other complex multicellular organisms, single-celled bacteria can fall ill and fight off viral infections. A bacterial virus is caused by a bacteriophage, or, more simply, phage, which is one of the most ubiquitous ...

Cell & Microbiology Oct 28, 2024

CRISPR-Cas10 can flood virally infected bacteria with toxic molecules, researchers discover

CRISPR-Cas9 has long been likened to a kind of genetic scissors, thanks to its ability to snip out any desired section of DNA with elegant precision.

Biotechnology Oct 28, 2024

Researchers discover underlying mechanisms that make CRISPR an effective gene editing tool

CRISPR/Cas9 is a gene editing tool that has revolutionized biomedical research and led to the first FDA-approved CRISPR-based gene therapy. However, until now, the precise mechanism of exactly how this tool works and avoids ...

Biotechnology Oct 2, 2024

Filament structure found to activate and regulate CRISPR-Cas 'protein scissors'

CRISPR-Cas systems help to protect bacteria from viruses. Several different types of CRISPR-Cas defense systems are found in bacteria, which differ in their composition and functions. Among them, the most studied proteins ...

Biotechnology Oct 1, 2024

Structure of a eukaryotic CRISPR-Cas homolog, Fanzor2, shows promise for gene editing

Scientists at St. Jude Children's Research Hospital have revealed how Fanzor2's divergence from bacterial ancestors may make it a useful tool for future genomic engineering endeavors.

Biotechnology Sep 25, 2024

CRISPR-Cas13: A new frontier in RNA-editing with therapeutic potential

In recent years, the scientific community has made significant strides in the field of gene editing, particularly through the development of the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) systems.

Biotechnology Sep 24, 2024

Increasing protein in staple crops could help alleviate global protein shortage

A Mississippi State biologist's research in improving global nutrition and sustainability is featured this week in New Phytologist.

Biotechnology Sep 23, 2024

Compact 'gene scissors' enable effective genome editing, may offer future treatment of high cholesterol gene defect

CRISPR-Cas is used broadly in research and medicine to edit, insert, delete or regulate genes in organisms. TnpB is an ancestor of this well-known "gene scissors" but is much smaller and thus easier to transport into cells.

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