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Cell & Microbiology Nov 22, 2024

New technique points to unexpected uses for snoRNA across many cell types

Dynamic, reversible modifications of DNA and RNA regulate how genes are expressed and transcribed, which can influence cellular processes, disease development, and overall organismal health. Small nucleolar RNAs (snoRNAs) ...

Astronomy Nov 15, 2024

Survey captures image sequence of galactic neighbors in the local universe

The National Institute for Astrophysics (INAF) has released images of five galaxies in the local universe, taken with the Italian VST ( VLT Survey Telescope) managed by INAF in Chile. The new images show these iconic galaxies ...

Bio & Medicine Nov 13, 2024

Improved lipid-polymer nanoparticle could advance inhalable mRNA medications and vaccines

Most people don't enjoy getting shots for treatments or vaccines. So, researchers are working to create more medicines, such as those made from messenger RNA (mRNA), that can be sprayed and inhaled.

Cell & Microbiology Nov 4, 2024

Newly described anti-viral defense system in bacteria aborts infection by chemically altering mRNA

Like humans and other complex multicellular organisms, single-celled bacteria can fall ill and fight off viral infections. A bacterial virus is caused by a bacteriophage, or, more simply, phage, which is one of the most ubiquitous ...

Cell & Microbiology Oct 17, 2024

DNA-binding C2H2 zinc finger proteins also regulate RNA processing, researchers discover

Researchers at the University of Toronto have shown that an important class of DNA-binding factors can also bind to RNA, regulating gene expression through various mechanisms. The study significantly expands our understanding ...

Cell & Microbiology Oct 16, 2024

Study maps role of microRNAs in early embryo development

Researchers at Karolinska Institutet have mapped how small RNA molecules, such as the recently Nobel Prize-awarded microRNAs, control cell development in the human embryo during the first days after fertilization. The findings, ...

Biochemistry Oct 16, 2024

First mRNA stabilizing substance could aid in development of innovative mRNA therapeutics

Messenger RNA–based therapeutics and vaccines are the new hope in the fight against incurable diseases. A commonly used strategy in the development of messenger RNA (mRNA) medicine is based on the destruction of disease-causing ...

Molecular & Computational biology Oct 10, 2024

High-resolution structural data shows how a supercomplex links mRNA translation and decay

Messenger RNA (mRNA) serves as a blueprint for proteins. When mRNA is no longer needed, it must be degraded. Director Elena Conti and her team at the Max Planck Institute of Biochemistry in Martinsried near Munich have now ...

Molecular & Computational biology Oct 7, 2024

What is microRNA? Nobel-winning discovery explained

The Nobel Prize in Medicine was awarded on Monday to two US scientists for discovering microRNA, a previously unknown type of genetic switch which is hoped can pave the way for new medical breakthroughs.

Molecular & Computational biology Oct 1, 2024

Research provides new insights into role of mechanical forces in gene expression

The genome inside each of our cells is modeled by tension and torsion—due in part to the activity of proteins that compact, loop, wrap and untwist DNA—but scientists know little about how those forces affect the transcription ...

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