A multidrug efflux pump in motion

Researchers at Vanderbilt University Medical Center have mapped the conformational changes that occur in a protein "notorious" for pumping chemotherapeutic drugs out of cancer cells and blocking medications from reaching ...

Experimental insecticide explodes mosquitoes, not honeybees

In a new study, Vanderbilt pharmacologist Jerod Denton, Ph.D., Ohio State entomologist Peter Piermarini, Ph.D., and colleagues report an experimental molecule that inhibits kidney function in mosquitoes and thus might provide ...

Chloride 'switch' turns on membrane formation

Chloride plays a key role in the formation of the basement membrane, a suprastructure on the outside of cells that undergirds and guides the function of most of the tissues of the body.

Ancient chemical bond may aid cancer therapy

A chemical bond discovered by Vanderbilt University scientists that is essential for animal life and which hastened the "dawn of the animal kingdom" could lead to new therapies for cancer and other diseases.

Frog-killing fungus paralyzes amphibian immune response

A fungus that is killing frogs and other amphibians around the world releases a toxic factor that disables the amphibian immune response, Vanderbilt University investigators report Oct. 18 in the journal Science.

New path for colon cancer drug discovery

An old pinworm medicine is a new lead in the search for compounds that block a signaling pathway implicated in colon cancer. The findings, reported by Vanderbilt University Medical Center researchers in the November issue ...

Newly discovered gene enables fish to 'disappear'

Researchers led by Vanderbilt's Roger Cone, Ph.D., have discovered a new member of a gene family that has powerful influences on pigmentation and the regulation of body weight.

page 2 from 3