Computer model identifies drug-resistant mutations

To counter drug resistance, scientists engineer new drugs to "fit" new mutations and thus kill the cancer cell or pathogen. Now, an NIBIB-funded team of Penn State engineers has a new approach for predicting which mutation ...

Disarming bacteria with mucus and phages

Millions of people are treated with antibiotics each year for infections or as a preventative measure. The Centers for Disease Control and Prevention reports that at least 2.8 million people are infected with antibiotic-resistant ...

Researchers identify how eye loss occurs in blind cavefish

Loss of eye tissue in blind cavefish (Astyanax mexicanus), which occurs within a few days of their development, happens through epigenetic silencing of eye-related genes, according to a study led by the National Institutes ...

Scientists teach computers how to analyze brain cells

In the early days of neuroscience research, scientists painstakingly stained brain cells and drew by hand what they saw in a microscope. Fast forward to 2018 and machines may be able to learn how to do that work. According ...

Study changes long-held concepts of cell decoding

Scientists at the National Institute on Drug Abuse (NIDA) Intramural Research Program (IRP) have uncovered evidence that shows a more complex and elaborate role for the body's hard-working G protein-coupled receptors (GPCRs) ...

Molecular secrets revealed: Antipsychotic docked in its receptor

Antipsychotic drugs—which transformed mental health care following their chance discovery in the mid-20th Century—may finally be poised for a long-overdue makeover incorporating structure-based design. Scientists funded ...

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