Researchers from the Hubrecht Institute (KNAW) have developed a new method to assess how production and degradation of gene transcripts are regulated. In this study, published in Science on the 6th of March, they found that ...
Biotechnology
Mar 6, 2020
1
19
Researchers of the Hubrecht Institute (KNAW) in Utrecht, The Netherlands, and the MRC Laboratory of Molecular Biology in Cambridge, United Kingdom, have discovered a new way in which the human body repairs DNA damage caused ...
Cell & Microbiology
Mar 4, 2020
1
1477
Researchers from the group of Hans Clevers at the Hubrecht Institute have developed a new genetic tool to label specific genes in human organoids, or mini organs. They used this new method, called CRISPR-HOT, to investigate ...
Cell & Microbiology
Mar 2, 2020
0
482
While the genome editing tool CRISPR/Cas9, developed in 2012, cuts a mutation out of a gene and replaces it with a gene-piece, a newer type of CRISPR, called base-editing, can repair a mutation without cutting the DNA. Therefore, ...
Molecular & Computational biology
Feb 20, 2020
0
24
Scientists from the Hubrecht Institute (KNAW) and the University of Cambridge (UK) have managed to generate complex embryo-like structures from mouse embryonic stem cells. These structures, called gastruloids, can now for ...
Cell & Microbiology
Feb 19, 2020
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21
hematopoietic stem cells (HSCs) are responsible for the constant replenishment of all blood cells throughout life. One of the major challenges in regenerative medicine is to produce tailor-made HSCs to replace the defective ...
Cell & Microbiology
Nov 4, 2019
0
46
DNA is the most important carrier of genetic information. Each cell contains approximately two meters of DNA. To ensure that all this genetic material fits into the small cell nucleus, it must be tightly packed. The DNA is, ...
Cell & Microbiology
Dec 4, 2023
0
1
Cells divide to produce new cells. A protein meshwork called the fibrous corona plays an important role during this process, as it ensures that DNA is evenly distributed over the new daughter cells. In collaboration with ...
Cell & Microbiology
Nov 13, 2023
0
1
Researchers in the group of Jeroen den Hertog, in collaboration with researchers in Leiden, have found that a compound inhibits a group of proteins called BMP receptors. This compound, called cercosporamide, was previously ...
Biochemistry
Sep 28, 2020
0
7
Researchers from the group of Vlad Cojocaru together with colleagues the Max Planck Institute in Münster (Germany) have revealed how an essential protein helps to activate genomic DNA during the conversion of regular adult ...
Cell & Microbiology
Feb 14, 2020
0
21
