The Gladstone Institutes is comprised of three institutes in the San Francisco area which began in 1979. The Gladstone Institute of Cardiovascular Disease focuses on atherosclerosis and its complications. The Gladstone Institute of Virology and Immunology focuses on the origins of HIV/AID and development of treatment and prevention. The Gladstone Institute of Neurological Disease focuses on Alzheimer's Disease and related aging factors. The Gladstone Institute is an independent center for research, however it is affiliated with the University of California, San Francisco. The Gladstone Institutes have entered into joint research ventures with Merck & Co. Inc to form the Center for Translational Research. The center's focus is to bring about rapid drug discoveries and to bridge the gap between traditional basic research and making available therapies to treat patient diseases.
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More than a million years ago, large chunks of the human genome were rearranged—a chance event during egg or sperm formation that led to the deletion, duplication, or reversal of sections of DNA. Those structural variants, ...
Evolution
Apr 27, 2023
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249
When it comes to oxygen, you can have too much of a good thing. Breathing air that contains higher levels of oxygen than the usual 21 percent found in Earth's atmosphere can cause organ damage, seizures, and even death in ...
Cell & Microbiology
Mar 9, 2023
0
138
Humans and chimpanzees differ in only one percent of their DNA. Human accelerated regions (HARs) are parts of the genome with an unexpected amount of these differences. HARs were stable in mammals for millennia but quickly ...
Evolution
Jan 13, 2023
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387
A new variation of the CRISPR-Cas9 gene editing system makes it easier to re-engineer massive quantities of cells for therapeutic applications. The approach, developed at Gladstone Institutes and UC San Francisco (UCSF), ...
Biotechnology
Aug 25, 2022
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83
If you want to track a person's activities for a day, you could call them up every ten minutes and ask what they're doing. Easier, though, would be to provide them with a journal to log their own actions. Scientists often ...
Biotechnology
Jul 28, 2022
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105
A while ago, some researchers had suggested that blocking a set of proteins, known as bromodomain and extraterminal (BET) proteins, might be a way to fight COVID-19. However, in a surprising study, scientists at Gladstone ...
Cell & Microbiology
Jul 19, 2022
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139
HIV researchers have long been trying to identify the specific cells that the virus prefers to infect and hide in. They know that HIV favors a special type of immune cells called memory CD4 T cells. But these cells come in ...
Cell & Microbiology
Jul 5, 2022
0
109
Imagine you're baking a cake, but you run out of salt. Even with the missing ingredient, the batter still looks like cake batter, so you stick it in the oven and cross your fingers, expecting to end up with something pretty ...
Cell & Microbiology
Jan 28, 2022
1
168
Over the past decade, the CRISPR genome-editing system has revolutionized molecular biology, giving scientists the ability to alter genes inside living cells for research or medical applications. Now, researchers at Gladstone ...
Biotechnology
Jan 5, 2022
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487
The progression from a round ball of cells to an embryo with a head and a tail is one of the most critical steps in an organism's development. But just how cells first start organizing themselves with directionality along ...
Cell & Microbiology
Jun 21, 2021
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