Thermotolerance is a biological process by which cells, tissues, or organisms acquire the capacity to survive and maintain function under elevated temperatures that would otherwise be lethal or damaging. It involves coordinated molecular responses including induction of heat shock proteins and molecular chaperones, stabilization of protein structure, remodeling of membranes, modulation of reactive oxygen species detoxification systems, and activation of protective signaling pathways such as heat shock factor (HSF)-mediated transcription. Thermotolerance can be constitutive or inducible, often developing after a mild heat pretreatment, and contributes to cellular homeostasis, proteostasis, and integrity of critical processes such as DNA replication, transcription, translation, and photosynthesis under thermal stress.
Laboratory and field experiments have repeatedly demonstrated that modifications to the process of photosynthesis or to the physical characteristics of plants can make crops more resilient to hotter temperatures.
Biotechnology
Jun 12, 2025
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Since the time of the ancient Greek physician Hippocrates, cancer has been recognized as being sensitive to heat. Today, this principle forms the basis of hyperthermia treatment—a promising cancer therapy that uses controlled ...
Cell & Microbiology
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Bio & Medicine
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