Page 2: Research news on Self-assembly

Self-assembly as a research area investigates the spontaneous organization of components into ordered structures driven by local interactions and thermodynamic or kinetic principles, without direct external manipulation of each element. It encompasses molecular, nanoscale, and mesoscale systems where noncovalent forces (e.g., van der Waals, electrostatic, hydrophobic, hydrogen bonding) or specific binding interactions encode structural information. Research focuses on understanding design rules, energy landscapes, and defect formation, as well as developing programmable systems (e.g., DNA origami, block copolymers, colloidal crystals) for applications in materials science, nanotechnology, and biotechnology, often linking equilibrium self-assembly with nonequilibrium and hierarchical assembly processes.

Building big with DNA gets a software upgrade

Forty-four years ago, Nadrian Seeman published his groundbreaking ideas on using DNA as a structural material, expanding DNA's significance far beyond its role as a carrier of genetic information. Since then, the steadily ...

Scientists discover a new way a disease-linked protein comes apart

Transthyretin amyloid disease (ATTR) is a progressive, life-threatening condition caused when the protein transthyretin (TTR) breaks apart and aggregates in the heart and other organs. One of the most common treatments, a ...

Flexible nanopores shed new light on Parkinson's and ALS

In a promising milestone for nanotechnology, Constructor University has contributed to a study demonstrating self-assembling nanopores capable of detecting disease proteins associated with illnesses like Parkinson's and ALS.

Fleeting sugar pairs may help curb abnormal cell-growth signals

Acting as armor, a scaffold and a communication platform in one, our cells' plasma membrane lies at the heart of many crucial cellular processes. Traditionally, it has been thought to function through interactions among its ...

How membraneless organelles assemble into organized protein hubs

Inside every cell, thousands of proteins must reach the right place at the right time. Helping coordinate this complex logistics network are centriolar satellites—tiny, membraneless organelles that play important roles in ...

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