Sample preparation is a fundamental laboratory technique encompassing all procedures required to convert a raw specimen into a form suitable for analytical measurement or experimental manipulation, while preserving analyte integrity and representativeness. It typically includes sampling, homogenization, separation, purification, concentration, and, when necessary, chemical derivatization. Methods vary by matrix and analytical modality (e.g., filtration, centrifugation, extraction, digestion, or fixation for microscopy), and are optimized to minimize contamination, losses, matrix effects, and chemical transformations. Rigorous sample preparation is critical for achieving accuracy, precision, sensitivity, and reproducibility in techniques such as chromatography, mass spectrometry, spectroscopy, and molecular biology assays.
A group of researchers at the VIB‑UGent Center for Medical Biotechnology has developed a new platform to isolate and analyze extracellular vesicles (EVs), nanosized particles secreted by cells and playing a role in cellular ...
Bio & Medicine
Jul 7, 2025
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22
A research group has developed a technology for mass-producing uniform artificial cells (lipid bilayer vesicles) with artificial model nuclei using microfluidic devices with high reproducibility. They also demonstrated that ...
Cell & Microbiology
Jun 19, 2025
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25
A research team, led by Professor Jimin Kwon from the Department of Electrical Engineering at UNIST, in collaboration with Professor Yong-Young Noh and his research team from the Department of Chemical Engineering at POSTECH, ...
Nanophysics
Mar 31, 2025
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52
Silicon is the best-known semiconductor material. However, controlled nanostructuring drastically alters the material's properties. Using a specially developed etching apparatus, a team at HZB has now produced mesoporous ...
Nanophysics
Feb 25, 2025
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64
Gas sensing technologies play a vital role in our modern world, from ensuring our safety in homes and workplaces to monitoring environmental pollution and industrial processes. Traditional gas sensors, while effective, often ...
Nanomaterials
Feb 25, 2025
0
30
So-called "infinite-layer" nickelate materials, characterized by their unique crystal and electronic structures, exhibit significant potential as high-temperature superconductors. Studying these materials remains challenging ...
Condensed Matter
Jan 17, 2025
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86
As the demand for thinner, lighter, and more flexible electronic devices grows, the need for advanced manufacturing processes has become critical. Polyimide (PI) films are widely used in these applications due to their excellent ...
Nanomaterials
Jan 8, 2025
0
57
A method that can grow a useful insulating material into exceptionally high-quality films that are just one atom thick and are suitable for industrial-scale production has been developed by an international team led by Xixiang ...
Nanomaterials
Dec 2, 2024
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71
A research team from Skoltech and other scientific organizations conducted a study to determine which conditions are the most suitable for storing graphene oxide—a promising material that can be used for manufacturing composite ...
Nanomaterials
Sep 24, 2024
0
59
Research teams from Wuhan University and the China University of Geosciences (Wuhan) have revealed new insights into the formation mechanism of nitrogen-vacancies (NV) centers in type-Ib diamonds, a phenomenon critical to ...
Condensed Matter
Sep 6, 2024
0
70
