Sample preparation is a fundamental laboratory technique encompassing all procedures required to convert a raw specimen into a form suitable for analytical measurement or experimental manipulation, while preserving analyte integrity and representativeness. It typically includes sampling, homogenization, separation, purification, concentration, and, when necessary, chemical derivatization. Methods vary by matrix and analytical modality (e.g., filtration, centrifugation, extraction, digestion, or fixation for microscopy), and are optimized to minimize contamination, losses, matrix effects, and chemical transformations. Rigorous sample preparation is critical for achieving accuracy, precision, sensitivity, and reproducibility in techniques such as chromatography, mass spectrometry, spectroscopy, and molecular biology assays.
A quick, purification-free method was developed by researchers at the Institute of Science Tokyo, to capture the detailed 3D structures of flexible sugar molecules. By growing crystals of galectin-10 protein using a cell-free ...
Biotechnology
Oct 30, 2025
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27
Some of the most expensive drugs currently in use are gene therapies to treat specific diseases, and their high cost limits their availability for those who need them. Part of the reason for the cost is that the manufacturing ...
Bio & Medicine
Oct 29, 2025
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28
An international team led by researchers at MPI-CPfS used irradiation with extremely high-energy electrons to controllably introduce atomic defects in superconducting nickelate thin films. Their systematic investigation recently ...
Superconductivity
Oct 24, 2025
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77
A research team led by Kyushu University has developed a new fabrication method for energy-efficient magnetic random-access memory (MRAM) using a new material called thulium iron garnet (TmIG) that has been attracting global ...
Condensed Matter
Oct 10, 2025
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95
In a study published in Journal of the American Chemical Society, a team led by Prof. Song Li from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences synthesized monolayer WS2 lateral ...
Nanomaterials
Sep 23, 2025
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25
A research team has successfully developed the technology to fabricate high-sensitive biosensors by simply spraying, like an inkjet printer. The technology enables the fabrication of sensitive and precise sensors without ...
Bio & Medicine
Sep 8, 2025
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31
Researchers have demonstrated a new fabrication approach that enables the exploration of a broader range of superconducting materials for quantum hardware.
Superconductivity
Sep 3, 2025
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212
In their quest to explore and characterize high-temperature superconductors, physicists have mostly focused on a material that is not the absolute highest. That's because that crystal is much easier to split into uniform, ...
DNA holds the instructions that make us who we are. If we want to read those instructions, say, to understand our predisposition to genetic disorders, we need to carefully "unzip" DNA's iconic double-helix structure. This ...
Bio & Medicine
Jul 30, 2025
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70
Haozhe "Harry" Wang, assistant professor of electrical and computer engineering (ECE) at Duke University and an expert in developing new methods for manufacturing materials, continues to push the boundaries in MXene research.
Nanomaterials
Jul 9, 2025
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34
