Re-epithelialization is a wound-healing biological process in which epithelial cells migrate, proliferate, and differentiate to restore the integrity of an epithelial barrier after injury. Following tissue damage, keratinocytes or other epithelial cells at the wound edge undergo phenotypic changes, including loss of stable cell–cell and cell–matrix adhesions, cytoskeletal reorganization, and increased motility, enabling them to crawl over the provisional matrix. Concurrently, cell proliferation replenishes the epithelial cell pool, while basement membrane components are remodeled and reassembled. Re-epithelialization is tightly regulated by growth factors, cytokines, extracellular matrix signals, and mechanical cues, and is essential for re-establishing tissue homeostasis and barrier function.
A decade ago this summer, at the Marine Biological Laboratory, Jocelyn Malamy watched jellyfish cells "walk" toward each other to close a wound for the first time. An associate professor of molecular genetics and cell biology ...
Plants & Animals
Jun 30, 2026
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Researchers in Taiwan have developed a cell-free extracellular matrix material from axolotl skin that helped mouse burn wounds close faster and show signs of reduced fibrotic scarring. The findings suggest that one of nature's ...
Cell & Microbiology
Jun 24, 2026
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11
What if a process we associate with aging actually helps the body heal? A study led by Mikolaj Ogrodnik, LBI Trauma, published in Nature Cell Biology, shows that cells enter a state of senescence within minutes to hours after ...
Cell & Microbiology
Jun 1, 2026
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25
Understanding how wounds heal after injury could be a step closer thanks to a new mathematical model developed by researchers at the University of Bristol. The study, published in Physical Review Letters, builds on previous ...
Cell & Microbiology
Apr 27, 2026
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53
When a wound on the skin creates a gap, the epithelial cells of the skin, surrounding the wound, move in a concerted fashion to close this gap. The boundaries of these gaps can have different curvatures; they could either ...
Cell & Microbiology
Aug 18, 2025
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168
A nanocellulose wound dressing that can reveal early signs of infection without interfering with the healing process has been developed by researchers at Linköping University, Sweden. Their study, published in Materials Today ...
Bio & Medicine
Apr 18, 2023
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165
The Indiana Center for Regenerative Medicine and Engineering (ICRME) at Indiana University School of Medicine is home to tissue nanotransfection (TNT) regenerative medicine technology that achieves functional tissue reprogramming ...
Bio & Medicine
Jul 18, 2022
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