Immune evasion is a biological process by which pathogens, tumor cells, or other aberrant cells avoid detection, recognition, or elimination by the host immune system, thereby promoting persistence and proliferation. Mechanisms include antigenic variation, downregulation or loss of major histocompatibility complex (MHC) molecules, expression of immune checkpoint ligands (e.g., PD-L1), secretion of immunosuppressive cytokines, induction of regulatory T cells or myeloid-derived suppressor cells, and shielding of antigens within biofilms or physical barriers. This process critically influences infection chronicity, tumor progression, vaccine efficacy, and the outcome of host–pathogen or host–tumor coevolution.
One of the most promising avenues in treating cancer is to restore our immune system's ability to recognize and attack cancerous cells. A team of University of Chicago chemists and biologists developed a tiny device that ...
Bio & Medicine
Mar 3, 2022
0
335
Researchers at Penn Medicine have discovered a new, more effective method of preventing the body's own proteins from treating nanomedicines like foreign invaders, by covering the nanoparticles with a coating to suppress the ...
Bio & Medicine
Jan 11, 2022
0
111
Researchers at Wake Forest School of Medicine have discovered that a nanoparticle therapeutic enhances cancer immunotherapy and is a possible new approach in treating malignant pleural effusion (MPE). MPE is the accumulation ...
Bio & Medicine
Dec 16, 2021
0
140
To grow and spread, cancer cells must evade the immune system. Investigators from Brigham and Women's Hospital and MIT used the power of nanotechnology to discover a new way that cancer can disarm its would-be cellular attackers ...
Bio & Medicine
Nov 18, 2021
0
297
Cell membrane coated biomimetic nanoparticles (NPs) have been widely studied in nanomedicine because of their unique properties such as immune escaping, long blood circulation, specific molecular recognition and efficient ...
Bio & Medicine
Sep 30, 2021
0
95
Cancer immunotherapy such as immune checkpoint blockade (ICB) is a revolutionary treatment against tumors by re-enforcing immune surveillance and even inducing long-term disease control.
Bio & Medicine
Sep 29, 2021
0
124
Tiny synthetic particles known as dendrimers avoid detection by our immune system and could help develop a new way to deliver drugs into the body without triggering a reaction.
Bio & Medicine
Aug 12, 2021
0
219
Immunotherapy has great potential in clinical cancer treatment due to systematic activation of antitumor immunity. However, low immunogenicity, or negative feedback on immunotherapy, greatly hinders the efficacy of currently ...
Bio & Medicine
Jul 16, 2021
0
97
A research team, led by Prof. Nathaniel S. Hwang and Prof. Byung-gee Kim, from Seoul National University (SNU) and Prof. Dong Yun Lee, from Hanyang University, has used enzymatic crosslinking to create nanofilms on cell surfaces. ...
Bio & Medicine
Jun 24, 2021
0
87
