Immune evasion is a biological process by which pathogens, tumor cells, or other aberrant cells avoid detection, recognition, or elimination by the host immune system, thereby promoting persistence and proliferation. Mechanisms include antigenic variation, downregulation or loss of major histocompatibility complex (MHC) molecules, expression of immune checkpoint ligands (e.g., PD-L1), secretion of immunosuppressive cytokines, induction of regulatory T cells or myeloid-derived suppressor cells, and shielding of antigens within biofilms or physical barriers. This process critically influences infection chronicity, tumor progression, vaccine efficacy, and the outcome of host–pathogen or host–tumor coevolution.
Washington State University researchers have discovered how the bacteria that cause anaplasmosis and Lyme disease hijack cellular processes in ticks to ensure their survival and spread to new hosts, including humans.
Cell & Microbiology
Jun 30, 2025
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41
A study led by a global research consortium offers new hope for patients with mycetoma, a neglected tropical disease. Researchers using an insect model and transcriptome analysis have unraveled the mechanism of iron regulation ...
Cell & Microbiology
Jun 25, 2025
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71
The H5N1 avian influenza virus has infected birds and mammals around the world. As of June 2025, 70 people have been infected, and one person has died in the United States. A new analysis suggests that the virus is evolving ...
Molecular & Computational biology
Jun 21, 2025
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104
A study to look at why long-lived bats do not get cancer has broken new ground about the biological defenses that resist the disease.
Plants & Animals
Jun 9, 2025
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172
Our immune system is designed to protect us by recognizing and attacking infected or abnormal cells. However, cancer cells often manage to "cheat" the immune system by pretending to be healthy cells and thus disabling immune ...
Bio & Medicine
Jun 4, 2025
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51
Researchers have developed an innovative nano-immune agonist that significantly improves immunotherapy outcomes for melanoma—a highly aggressive and hard-to-treat form of skin cancer.
Bio & Medicine
Apr 22, 2025
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30
Researchers from Auburn University, partnering with the University of Basel in Switzerland, have discovered a new way to make a cancer-targeting protein complex more stable, opening doors to better cancer treatments. Led ...
Bio & Medicine
Nov 14, 2024
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27
The tumor microenvironment—an ad hoc, messy amalgamation of signaling molecules, immune cells, fibroblasts, blood vessels, and the extracellular matrix—acts like a "powerful security system that protects solid tumors from ...
Bio & Medicine
Sep 4, 2024
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77
A drug-carrying molecule designed to cure disease by slipping past the lung's natural defenses offers new hope for people with chronic or deadly respiratory diseases, say its creators, researchers in assistant professor Liheng ...
Bio & Medicine
Aug 22, 2024
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117
Phototherapy is a safe and effective method for tumor treatment, including photothermal therapy (PTT) and photodynamic therapy (PDT). PTT refers to the use of laser to activate photothermal conversion agents and use high ...
Bio & Medicine
Jun 14, 2024
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