Immune evasion is a biological process by which pathogens, tumor cells, or other aberrant cells avoid detection, recognition, or elimination by the host immune system, thereby promoting persistence and proliferation. Mechanisms include antigenic variation, downregulation or loss of major histocompatibility complex (MHC) molecules, expression of immune checkpoint ligands (e.g., PD-L1), secretion of immunosuppressive cytokines, induction of regulatory T cells or myeloid-derived suppressor cells, and shielding of antigens within biofilms or physical barriers. This process critically influences infection chronicity, tumor progression, vaccine efficacy, and the outcome of host–pathogen or host–tumor coevolution.
Japan's Innovation Center of NanoMedicine reports on a new stealth coating for tiny medicine-carrying particles that doesn't depend on PEG-style shields. By locking positive and negative charges together into a tight net, ...
Cancer immunotherapy, which uses drugs that stimulate the body's immune cells to attack tumors, is a promising approach to treating many types of cancer. However, it doesn't work well for some tumors, including ovarian cancer.
Bio & Medicine
Oct 31, 2025
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Scientists have discovered how one of the world's most destructive plant diseases manages to slip past crops' defenses—a breakthrough that could help farmers grow stronger, more resilient plants.
Cell & Microbiology
Oct 20, 2025
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102
Nanomedicine uses ultra-small particles to deliver drugs directly to the tissues and cells that need them, improving treatment effectiveness while reducing side effects. This approach underpins some clinically approved RNA-based ...
Bio & Medicine
Oct 16, 2025
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Viruses are masters at taking over our cells: They disable our defenses and hijack the cellular machinery in order to multiply successfully. For example, the herpes simplex virus 1, which causes blister-like skin rashes, ...
Cell & Microbiology
Oct 15, 2025
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Since the 1940s, antibiotics have been our primary weapon against harmful bacterial infections. But some stubborn pathogens, like Staphylococcus aureus, can infect and hide within our own immune cells, making it incredibly ...
Molecular & Computational biology
Oct 14, 2025
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Population bottlenecks caused by stark population loss due to illness or habitat destruction caused mammals' disease immunity to decline, according to a new study led by computational biologists in the Penn State School of ...
Evolution
Sep 30, 2025
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Skoltech researchers and their colleagues from the Pasteur Institute and the University of Lorraine, France, have uncovered some of the inner workings of a recently discovered bacterial immune system called PARIS, which can ...
Cell & Microbiology
Sep 25, 2025
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The notorious pathogen that caused the Irish Potato Famine in the 1840s is still a major threat to potato and tomato crops worldwide. This oomycete water mold, Phytophthora infestans, can devastate entire fields, posing a ...
Molecular & Computational biology
Sep 10, 2025
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27
Aphids, grasshoppers and other bugs aren't the only pests that can quickly wipe out a crop. Many harmful bacteria have evolved ways to bypass a plant's defenses. A once-healthy tomato plant can quickly turn sick and blotchy, ...
Molecular & Computational biology
Sep 9, 2025
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