Genomes, as physical systems, comprise the complete set of nucleic acid molecules (typically DNA, or RNA in some viruses) that encode the hereditary information of an organism, including all chromosomes and extrachromosomal genetic elements. They are organized into linear or circular polymers of nucleotides, with specific higher-order structures such as chromatin in eukaryotes or nucleoid organization in prokaryotes. At the physical level, genomes exhibit defined sequence composition, length, and structural features (e.g., replication origins, regulatory regions, repetitive elements) that collectively determine their stability, replication dynamics, mutational patterns, and interactions with cellular molecular machinery.
Metagenomics relies on the use of software programs called assemblers, which can reconstruct tens of thousands of individual microbial genomes from DNA sequencing of samples such as soil, bodily fluids, or clinical swabs ...
Cell & Microbiology
Apr 22, 2026
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In the spring, ants are once again hard at work. Beyond their everyday presence, ants are also key model organisms in cutting-edge evolutionary genetics research, helping scientists understand how social behavior and cooperation ...
Evolution
Apr 20, 2026
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19
For the first time, a research team at the Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) has succeeded in reducing the size of, or even completely removing, chromosomes in plants with large genomes, such ...
Biotechnology
Apr 17, 2026
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Scientists from Skoltech and the University of Potsdam have developed a physical theory that sheds light on how molecular motors organize the three-dimensional structure of the genome. Using theoretical polymer physics and ...
Molecular & Computational biology
Apr 16, 2026
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26
Research has shed important new light on the enemies-turned-allies that allow bacteria to exchange genes, including those linked to antimicrobial resistance (AMR). The insights, which expand our understanding of the major ...
Cell & Microbiology
Apr 16, 2026
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A massive study of ancient DNA from nearly 16,000 people across more than 10,000 years in West Eurasia reveals that natural selection has shaped modern human genomes far more than previously thought.
Evolution
Apr 15, 2026
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226
A research team has discovered an enhanced CRISPR gene-editing system that could enable targeted delivery inside the human body—a key step toward broader clinical use. Researchers identified a naturally occurring enzyme, ...
Biotechnology
Apr 13, 2026
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70
Weill Cornell Medicine researchers have found that temporarily disabling a protein complex that organizes DNA into loops inside the cell's nucleus drastically disrupted the three-dimensional structure of the genome, but surprisingly, ...
Cell & Microbiology
Apr 13, 2026
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What if the Trojan horse had been pulled to pieces, revealing the ruse and fending off the invasion, just as it entered the gates of Troy? That's an apt description of a newly characterized bacterial defense system that chops ...
Cell & Microbiology
Apr 10, 2026
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113
DNA inside the nucleus is not packed as a rigid regular fiber—linker histone H1 dynamically binds and loosely "glues" nucleosomes together, creating a dynamic, fluid organization that can still support essential genome functions.
Cell & Microbiology
Apr 9, 2026
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