Scientists chart over 140,000 DNA loops to map human chromosomes in the nucleus
One of the most detailed 3D maps of how the human chromosomes are organized and folded within a cell's nucleus is published in Nature.
Page 22: Research news on Genomes
Genomes, as physical systems, comprise the complete set of nucleic acid molecules (typically DNA, or RNA in some viruses) that encode the hereditary information of an organism, including all chromosomes and extrachromosomal genetic elements. They are organized into linear or circular polymers of nucleotides, with specific higher-order structures such as chromatin in eukaryotes or nucleoid organization in prokaryotes. At the physical level, genomes exhibit defined sequence composition, length, and structural features (e.g., replication origins, regulatory regions, repetitive elements) that collectively determine their stability, replication dynamics, mutational patterns, and interactions with cellular molecular machinery.
Opposing forces in cells could hold clues to treating disease
A newly revealed molecular tug-of-war may have implications for better understanding how a multitude of diseases and disorders—including cancers, neurodegenerative diseases and immune disorders—originate, as well as how to ...
Cell & Microbiology
Dec 16, 2025
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Evaluating the evaluators: How do plant virus genome analysis tools stack up?
Research relies on replication: Different teams need to make the same conclusion multiple times before a consensus is reached and the finding can be built upon or applied. More may rest on the tools researchers use than previously ...
Molecular & Computational biology
Dec 15, 2025
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How to build a genome: Scientists release troubleshooting manual for synthetic life
Leading synthetic biologists have shared hard-won lessons from their decade-long quest to build the world's first synthetic eukaryotic genome in a Nature Biotechnology paper. Their insights could accelerate development of ...
Biotechnology
Dec 11, 2025
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Biobanking opens new windows into human evolution
More than a decade after the first Neanderthal genome was sequenced, scientists are still working to understand how human-specific DNA changes shaped human evolution.
Evolution
Dec 10, 2025
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Unexpected protein fold links bacteria, viruses, and eukaryotes in DNA management
An investigation into cellular components in bacteria has unexpectedly uncovered a feature with relevance across many life forms, paving the way for diverse research, biotechnical and medical applications.
Cell & Microbiology
Dec 8, 2025
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Uncovering the principle by which DNA replication initiation sites are determined in the human genome
When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular aging, cancer, and genetic disorders. ...
Cell & Microbiology
Dec 2, 2025
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Thousands of genomes reveal the wild wolf genes in most dogs' DNA
Dogs were the first of any species that people domesticated, and they have been a constant part of human life for millennia. Domesticated species are the plants and animals that have evolved to live alongside humans, providing ...
Evolution
Nov 27, 2025
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136
Unlocking the genome's hidden half with new DNA sequencing technology
Cornell researchers have found that a new DNA sequencing technology can be used to study how transposons move within and bind to the genome. Transposons play critical roles in immune response, neurological function and genetic ...
Biotechnology
Nov 21, 2025
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253
Protein droplets in the nucleus guard against cancer, researchers discover
Scientists at the Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, have discovered how a gene-regulating protein forms tiny liquid-like droplets inside the cell nucleus (the compartment that stores and manages ...
Cell & Microbiology
Nov 21, 2025
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