Genetically engineered organisms (GEOs) are biological entities—prokaryotic or eukaryotic—whose genomes have been deliberately modified using recombinant DNA technologies, genome editing tools (e.g., CRISPR-Cas systems, TALENs, ZFNs), or transgenic methods to introduce, delete, or alter specific genetic sequences. This topic encompasses the design, construction, and characterization of modified genomes; vector systems and delivery methods; control of gene expression; and assessment of phenotypic consequences, stability, and off-target effects. It also includes applications in basic research, biotechnology, agriculture, biopharmaceutical production, and synthetic biology, as well as associated biosafety, containment, and regulatory frameworks governing experimental and environmental use.
Targeting malignant tumors with high precision is challenging for biomedical researchers. However, this scenario is likely to witness a paradigm shift in the near future through the use of specially engineered bacteria that ...
Bio & Medicine
Aug 29, 2023
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In-cell engineering can be a powerful tool for synthesizing functional protein crystals with promising catalytic properties, show researchers at Tokyo Tech. Using genetically modified bacteria as an environmentally friendly ...
Bio & Medicine
Jul 25, 2023
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Two unfortunate facts about chemotherapy: It can harm healthy cells as well as cancerous ones, and many therapeutic targets stay within cancer cells, making them harder to reach.
Bio & Medicine
Jul 24, 2023
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Gene therapies have the potential to treat neurological disorders like Alzheimer's and Parkinson's diseases, but they face a common barrier—the blood-brain barrier. Now, researchers at the University of Wisconsin-Madison ...
Bio & Medicine
Jan 19, 2023
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Photothermal therapy (PTT) has attracted considerable attention for the treatment of tumors because it is minimally invasive and has spatiotemporal selectivity.
Bio & Medicine
Jan 13, 2023
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RIKEN biologists have found an effective way to smuggle genetic material into the energy generators of plant cells, opening up the possibility of coaxing plants to produce commercially useful compounds. Their research appears ...
Bio & Medicine
Nov 2, 2022
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A team of researchers at Northwestern University has devised a new platform for gene editing that could inform the future application of a near-limitless library of CRISPR-based therapeutics.
Bio & Medicine
Oct 6, 2022
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Artificial cells have been engineered to mimic the natural characteristics of biological cells in a new study from Imperial College London.
Bio & Medicine
Jun 13, 2022
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For nearly 40 years, drugmakers have used genetically engineered cells as tiny drug factories. Such cells can be programmed to secrete compounds that yield drugs used to treat cancer and autoimmune conditions such as arthritis.
Bio & Medicine
Apr 20, 2022
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Researchers at the RIKEN Center for Sustainable Resource Science (CSRS) in Japan have developed a way to improve crop quality without needing to create special genetically modified plants. Rather that changing plant genomes, ...
Bio & Medicine
Feb 23, 2022
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