Research news on genetically engineered organisms

Genetically engineered organisms (GEOs) are biological entities—prokaryotic or eukaryotic—whose genomes have been deliberately modified using recombinant DNA technologies, genome editing tools (e.g., CRISPR-Cas systems, TALENs, ZFNs), or transgenic methods to introduce, delete, or alter specific genetic sequences. This topic encompasses the design, construction, and characterization of modified genomes; vector systems and delivery methods; control of gene expression; and assessment of phenotypic consequences, stability, and off-target effects. It also includes applications in basic research, biotechnology, agriculture, biopharmaceutical production, and synthetic biology, as well as associated biosafety, containment, and regulatory frameworks governing experimental and environmental use.

Sharpening an essential tool for biotechnology

Scientists at the Department of Energy (DOE)'s Oak Ridge National Laboratory (ORNL) have shown that more than 93% of possible E. coli CRISPR-Cas9 guide RNAs—molecules that direct the gene-editing CRISPR tool to the right ...

Spinach peptide discovery leads to citrus greening treatment

A citrus greening disease treatment rooted in more than a decade of research at Texas A&M AgriLife Research has reached a milestone on the path to commercial availability. The U.S. Environmental Protection Agency has granted ...

Building real-time control for engineered biological systems

Scientists can engineer living cells to perform useful tasks, from producing medicines and sustainable chemicals to detecting disease. Unlike traditional engineered systems, living cells are constantly changing as they grow, ...

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