Research news on genetically engineered organisms

Genetically engineered organisms (GEOs) are biological entities—prokaryotic or eukaryotic—whose genomes have been deliberately modified using recombinant DNA technologies, genome editing tools (e.g., CRISPR-Cas systems, TALENs, ZFNs), or transgenic methods to introduce, delete, or alter specific genetic sequences. This topic encompasses the design, construction, and characterization of modified genomes; vector systems and delivery methods; control of gene expression; and assessment of phenotypic consequences, stability, and off-target effects. It also includes applications in basic research, biotechnology, agriculture, biopharmaceutical production, and synthetic biology, as well as associated biosafety, containment, and regulatory frameworks governing experimental and environmental use.

Seed banks may complicate gene drives aimed at controlling weeds

Gene drives—a genetic engineering approach that quickly spreads specific genetic changes throughout a population, whether to kill it off or add a new trait—may have potential for controlling weeds. But so far, gene drives ...

Nanoparticles can genetically modify several human cell types

In a demonstration that could help pave the way for gene therapies with fewer side effects, several human cell types have been genetically modified with protein nanoparticles designed at University of Michigan Engineering ...

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