DNA sequencing is a set of laboratory methods for determining the precise linear order of nucleotides (A, C, G, T) in a DNA molecule. Core methodological classes include Sanger sequencing, which uses chain-terminating dideoxynucleotides and capillary electrophoresis for high-fidelity, low-throughput analysis, and next-generation sequencing (NGS) platforms, which employ massively parallel sequencing-by-synthesis, sequencing-by-ligation, or nanopore-based readout for high-throughput, genome-scale applications. These methods entail library preparation, clonal or single-molecule amplification (except in true single-molecule approaches), signal detection, and computational base-calling, followed by quality control and downstream bioinformatic analysis.
It is not uncommon for a body to be moved after a murder, usually to hide or eliminate evidence. And while the Arizona desert may seem like the perfect place to commit such a crime, a new study shows that a cadaver can still ...
Cell & Microbiology
Mar 11, 2026
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A research team led by scientists at the Butantan Institute in São Paulo, Brazil, has completed the most extensive genetic sequencing of a jararaca viper to date. The focus of the study was the genome of the golden lancehead ...
Evolution
Mar 11, 2026
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44
Researchers at Cardiff University have uncovered how a particularly severe form of DNA damage arises—shedding new light on mutation processes that contribute to cancer and inherited genetic conditions. The study, led by Dr. ...
Cell & Microbiology
Mar 10, 2026
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40
Long before humans cultivated crops or sailed between continents, a group of plant viruses was already evolving among wild plants in Eurasia. According to a new international study published in Plant Disease, the ancestors ...
Evolution
Mar 9, 2026
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20
Soybean cyst nematode (SCN) is among the most damaging pests affecting soybean crops around the world, with current management strategies relying primarily on a very narrow set of resistant soybean varieties, along with crop ...
Cell & Microbiology
Mar 5, 2026
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20
Even though farmers have been dealing with rice stink bugs as pests since the 1880s, entomologists are still getting to know them at the genetic level. A first-of-its-kind study published on the genetics of rice stink bugs ...
Molecular & Computational biology
Feb 28, 2026
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60
Duckweed is the fastest-growing flowering plant, but new knowledge of duckweed genetics discovered by Adelaide University researchers could lead to even faster growing rates. The research team, led by Professor Nikolai Borisjuk ...
Molecular & Computational biology
Feb 27, 2026
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45
In 2013, farmers in the highlands of Ethiopia began to notice something unsettling: a familiar variety of wheat was failing in an unfamiliar way. Stems weakened, plants collapsed, and fields that had once held firm against ...
Biotechnology
Feb 23, 2026
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52
There may be twice as many vertebrates on the planet as previous estimates claimed, according to a new study published in the journal Proceedings of the Royal Society B: Biological Sciences. That's not because of any errors ...
Scientists have pinpointed crucial genetic resistance to a fungal disease that threatens the global banana supply in a wild subspecies of the fruit. In a valuable step forward for banana breeding programs, Dr. Andrew Chen ...
Molecular & Computational biology
Feb 18, 2026
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