DNA sequencing is a set of laboratory methods for determining the precise linear order of nucleotides (A, C, G, T) in a DNA molecule. Core methodological classes include Sanger sequencing, which uses chain-terminating dideoxynucleotides and capillary electrophoresis for high-fidelity, low-throughput analysis, and next-generation sequencing (NGS) platforms, which employ massively parallel sequencing-by-synthesis, sequencing-by-ligation, or nanopore-based readout for high-throughput, genome-scale applications. These methods entail library preparation, clonal or single-molecule amplification (except in true single-molecule approaches), signal detection, and computational base-calling, followed by quality control and downstream bioinformatic analysis.
Researchers have developed a powerful new tool that can track how microbes spread between people with unprecedented precision, offering new ways to prevent infections and improve treatments in the future. The research, published ...
Cell & Microbiology
Apr 24, 2026
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10
An international team of researchers has produced complete, gap-free genome sequences for six peanut varieties, providing a comprehensive blueprint for future peanut breeding and improvement strategies.
Molecular & Computational biology
Apr 24, 2026
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14
In a first-of-its-kind finding, researchers at University of Iowa Health Care discovered that specific genetic sequences have an outsized impact on humans' language abilities and that these sequences evolved before humans ...
Evolution
Apr 23, 2026
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233
Research into human genomic diversity has a number of applications in biomedicine, evolution, and history. However, many populations have historically been underrepresented on the human genomic map. This is the case of Native ...
Evolution
Apr 22, 2026
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Metagenomics relies on the use of software programs called assemblers, which can reconstruct tens of thousands of individual microbial genomes from DNA sequencing of samples such as soil, bodily fluids, or clinical swabs ...
Cell & Microbiology
Apr 22, 2026
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11
Protein engineering is a field primed for artificial intelligence research. Each protein is made up of amino acids; to optimize a protein function, researchers modify proteins by switching out one of 20 different amino acids ...
Molecular & Computational biology
Apr 19, 2026
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90
Research has shed important new light on the enemies-turned-allies that allow bacteria to exchange genes, including those linked to antimicrobial resistance (AMR). The insights, which expand our understanding of the major ...
Cell & Microbiology
Apr 16, 2026
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Sequencing the DNA of all complex life in the UK and Ireland could generate up to almost £3 billion for the economy across agriculture, conservation, and research over the next 30 years, according to a new report.
Ecology
Apr 15, 2026
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7
A genetic master map of ancient grasses could be the key to future-proofing global food supplies, according to a new study revealing why some crops are naturally better at surviving climate change than others.
Evolution
Apr 14, 2026
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10
Evolution works over millennia. Climate change is moving far faster. That mismatch is killing some of the planet's most vital ecosystems, from California's towering redwoods to the seagrass meadows along its coast, both of ...
Ecology
Apr 10, 2026
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