Page 7: Research news on developmental biology

Developmental biology is the branch of biological sciences that investigates the processes by which organisms grow, differentiate, and acquire their form from fertilization to adulthood and often through regeneration and aging. It integrates molecular genetics, cell biology, genomics, and systems biology to elucidate mechanisms such as cell fate specification, pattern formation, morphogenesis, and organogenesis. Developmental biology examines regulatory gene networks, signaling pathways (e.g., Wnt, Hedgehog, Notch, TGF-β), epigenetic modifications, and mechanical forces that coordinate spatial and temporal control of gene expression and cellular behavior, providing a framework for understanding congenital disorders, tissue regeneration, and evolutionary changes in body plans.

Building a reference manual for how cells connect with each other

Every multicellular organism, from tiny worms to humans, elephants, and whales, needs a way for their cells to connect with each other to form tissues, organs, and organize their overall body plan. Cells have a variety of ...

Embryogenesis in 4D: A developmental atlas for genes and cells

How does a tiny cluster of cells become an embryo with a head, trunk, and tail? And how do thousands of genes coordinate this development? A new imaging method makes it possible to visualize the activity of thousands of genes ...

How cells work together: The mathematics behind biological shapes

How do biological cells join forces to form a structure? In her Ph.D. research, Daphne Nesenberend uses mathematics to show how forces and cooperation between cells create structure—and how simulations and experiments can ...

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