Research news on developmental biology

Developmental biology is the branch of biological sciences that investigates the processes by which organisms grow, differentiate, and acquire their form from fertilization to adulthood and often through regeneration and aging. It integrates molecular genetics, cell biology, genomics, and systems biology to elucidate mechanisms such as cell fate specification, pattern formation, morphogenesis, and organogenesis. Developmental biology examines regulatory gene networks, signaling pathways (e.g., Wnt, Hedgehog, Notch, TGF-β), epigenetic modifications, and mechanical forces that coordinate spatial and temporal control of gene expression and cellular behavior, providing a framework for understanding congenital disorders, tissue regeneration, and evolutionary changes in body plans.

Mapping how a single cell becomes an entire mouse

Growing inside each of us is a cellular family tree. Every one of the 37 trillion cells in our body is generated from another cell, going all the way back to a single fertilized egg. Much like we can draw a family tree tracking ...

A 'reality check' for lab-grown human embryo models

University of Sydney researchers have developed a new way to test how closely lab-grown biological models resemble real human embryos, finding that while some models perform well, none yet fully capture the complexity of ...

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