Biomolecules, as physical systems, are distinct molecular entities synthesized or utilized by living organisms that exhibit specific structural, thermodynamic, and dynamical properties enabling biological function. They include nucleic acids, proteins, lipids, carbohydrates, and diverse metabolites, each characterized by defined covalent connectivity, three-dimensional conformations, and interaction potentials with solvents, ions, and other biomolecules. Their behavior is governed by quantum-mechanical bonding, classical electrostatics, and statistical thermodynamics, leading to emergent phenomena such as self-assembly, allostery, enzyme catalysis, and molecular recognition. In physical systems research, biomolecules are studied through techniques like spectroscopy, crystallography, cryo-EM, and molecular simulations to elucidate structure–function relationships and energy landscapes.
All cells need to sense and respond to their environment, to know when to activate genes, build proteins, and carry out their basic functions. One of the most well-studied cellular responses is how they react during times ...
Cell & Microbiology
Dec 4, 2025
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A new tool developed by Helmholtz Munich and the German Center for Diabetes Research and the University of Bonn makes spatial proteomics and lipidomics easier to use—no coding required. C-COMPASS allows scientists to profile ...
Cell & Microbiology
Dec 4, 2025
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Researchers at National Taiwan University have uncovered, for the first time at atomic resolution, how the human proteasome recognizes branched ubiquitin chains. Their finding reveals a multivalent decoding mechanism that ...
Molecular & Computational biology
Dec 3, 2025
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Every second, trillions of tiny parcels travel through your bloodstream—carrying vital information between your body's cells. Now, scientists at the Baker Heart and Diabetes Institute have opened this molecular mail for the ...
Cell & Microbiology
Nov 29, 2025
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90
Using catalytic chemistry, researchers at Institute of Science Tokyo have achieved dynamic control of artificial membranes, enabling life-like membrane behavior. The work is published in the Journal of the American Chemical ...
Cell & Microbiology
Nov 28, 2025
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A technology developed in the laboratory of Prof. Amit Meller from the Technion—Israel Institute of Technology Faculty of Biomedical Engineering marks a significant advancement toward rapid proteome analysis, with far-reaching ...
Bio & Medicine
Nov 25, 2025
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Multicellular organisms (animals, plants, humans) all have the ability to methylate the cytosine base in their DNA. This process, a type of epigenetic modification, plays an important role in conditions such as cancer and ...
Evolution
Nov 18, 2025
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166
RNA plays a vital role in how our genes are expressed and how diseases develop. Yet, because RNA molecules constantly change shape, understanding how they work has long been a major scientific challenge.
Cell & Microbiology
Nov 13, 2025
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Pictures of DNA often look very tidy—the strands of the double helix neatly wind around each other, making it seem like studying genetics should be relatively straightforward. In truth, these strands aren't often so perfectly ...
Biotechnology
Nov 11, 2025
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The chains of amino acids that make up proteins are critical to every form of life. The complex ways that these proteins fold and interact has fascinated researchers for decades. Exactly how a protein folds determines its ...
Molecular & Computational biology
Nov 7, 2025
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