Biomolecules, as physical systems, are distinct molecular entities synthesized or utilized by living organisms that exhibit specific structural, thermodynamic, and dynamical properties enabling biological function. They include nucleic acids, proteins, lipids, carbohydrates, and diverse metabolites, each characterized by defined covalent connectivity, three-dimensional conformations, and interaction potentials with solvents, ions, and other biomolecules. Their behavior is governed by quantum-mechanical bonding, classical electrostatics, and statistical thermodynamics, leading to emergent phenomena such as self-assembly, allostery, enzyme catalysis, and molecular recognition. In physical systems research, biomolecules are studied through techniques like spectroscopy, crystallography, cryo-EM, and molecular simulations to elucidate structure–function relationships and energy landscapes.
The blobfish, once considered the ugliest animal in the world, has since had quite the redemption arc. Years after it was first discovered, scientists realized that the deep-sea creature appeared so unnervingly blobby only ...
Cell & Microbiology
Mar 23, 2026
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An extensive computational study by researchers from Finland's University of Jyväskylä predicts that gold nanoclusters could selectively recognize chiral biomolecules. This property may help in detecting certain diseases ...
Bio & Medicine
Mar 16, 2026
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A team of US researchers has gained new insights into how large protein molecules consistently fold themselves into useful shapes. Using a new approach to fluorescence microscopy, Hoi Sung Chung and colleagues at the National ...
Alzheimer's disease affects millions of people around the world. To study this condition, researchers must peer inside the distinctive environment of the human brain. but for scientists to get the most accurate picture of ...
Molecular & Computational biology
Mar 12, 2026
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13
A team from University of Toronto Engineering is the first to synthesize long noncoding RNA (lncRNA) outside the cell—a new approach to drug discovery that has already yielded some promising anti-inflammatory molecules. The ...
Biotechnology
Mar 10, 2026
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112
Materials that encourage mineralization, mimicking the process in the human body, are becoming increasingly important in medicine and technology. This process, which occurs at the interface between inorganic materials and ...
Bio & Medicine
Mar 10, 2026
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Researchers from the University of Nottingham have uncovered a surprising biological quirk in domestic cats that may help explain why they are so prone to chronic kidney disease. Unlike dogs and most other mammals, cats appear ...
Veterinary medicine
Mar 4, 2026
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Researchers from Tokyo Metropolitan University have created a new molecule which carries DNA into biological cells, to treat or vaccinate against illnesses. Many existing options rely on molecules with a strong positive charge, ...
Bio & Medicine
Feb 23, 2026
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80
Imagine trying to design a key for a lock that is constantly changing its shape. That is the exact challenge we face in modern drug discovery when dealing with intrinsically disordered proteins.
Since the dawn of the computer age, researchers have wrestled with two persistent challenges: how to store ever-increasing reams of data and how to protect that information from unintended access. Now, researchers with Arizona ...
Bio & Medicine
Feb 5, 2026
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