Biomolecular and subcellular processes constitute a research area focused on the molecular mechanisms and dynamic interactions that underlie cellular function, organization, and regulation at nanometer to micrometer scales. It encompasses studies of protein folding and trafficking, nucleic acid structure and metabolism, signal transduction, membrane transport, organelle biogenesis, cytoskeletal dynamics, and macromolecular complex assembly. This field integrates biochemical, biophysical, structural, imaging, and computational approaches to quantify reaction kinetics, spatial organization, and emergent behaviors within cells, aiming to relate molecular-level events to higher-order cellular phenotypes, robustness, and dysfunction in contexts such as development, stress responses, and disease.
Intrinsically disordered proteins lack a fixed structure, which is why they have been considered "undruggable" targets for drug development for years. However, these proteins play a key role in numerous diseases—ranging from ...
Molecular & Computational biology
Mar 3, 2026
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13
Antisense oligonucleotides (ASOs), used to treat genetic diseases, can affect how cells repair damage to their DNA. This is shown in a new study from Karolinska Institutet, published in Nature Communications. The findings ...
Biotechnology
Mar 3, 2026
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18
Multiphoton microscopy is used in biomedical research to study cells and tissues. Today, so-called two-photon microscopy is used to study processes within cells, but the technique has limitations in terms of image resolution. ...
Optics & Photonics
Mar 2, 2026
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81
To further the quantitative understanding of cellular decision making, Dr. Gregory Reeves and his team in the chemical engineering department have worked to interpret how a transcription factor dictates the alteration of ...
Molecular & Computational biology
Feb 28, 2026
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23
Researchers at the Weill Institute for Cell and Molecular Biology have uncovered new evidence that two major types of gene-controlling DNA sequences, promoters and enhancers, operate with a shared logic and often perform ...
Biotechnology
Feb 27, 2026
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90
RIKEN researchers have discovered how an enzyme modifies gene expression by targeting certain stretches of messenger RNA (mRNA) while leaving others alone. This finding could contribute to the rational design of drugs that ...
Biotechnology
Feb 26, 2026
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19
An international team of scientists has shed light on the development of the malaria parasite and has identified a unique protein essential for its survival and transmission, which offers a promising new target for antimalaria ...
Cell & Microbiology
Feb 26, 2026
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20
Cells rely on biomolecular condensates to coordinate essential biological processes without surrounding membranes. These droplet-like dynamic assemblies control the way in which DNA is turned into proteins, help clear cellular ...
Cell & Microbiology
Feb 25, 2026
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50
Studying gene expression in a cancer patient's cells can help clinical biologists understand the cancer's origin and predict the success of different treatments. But cells are complex and contain many layers, so how the biologist ...
Cell & Microbiology
Feb 25, 2026
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19
The human body is a dynamic place. Blood pumps, spinal fluid flows, oxygen comes in and carbon dioxide goes out. Deeper still, charged molecules pass through cell walls, quietly keeping the body's systems in balance. A new ...
Cell & Microbiology
Feb 25, 2026
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