Bioinformatics is a computational and analytical technique that applies algorithms, statistical methods, and database technologies to the acquisition, storage, processing, and interpretation of biological data, particularly large-scale omics datasets such as genomes, transcriptomes, and proteomes. It encompasses sequence alignment, gene prediction, variant calling, structural modeling, functional annotation, and systems-level network analysis. Bioinformatics pipelines integrate heterogeneous data types, automate quality control, and support reproducible research through workflow management and version-controlled code. As a technique, it enables hypothesis generation, biomarker discovery, and rational design in fields including molecular biology, genomics, pharmacology, and systems biology by transforming raw high-throughput experimental outputs into interpretable, quantitative biological insight.
Proteins sustain life as we know it, serving many important structural and functional roles throughout the body. But these large molecules have cast a long shadow over a smaller subclass of proteins called microproteins.
Biotechnology
Jul 31, 2025
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178
Recent advances in computational protein design have depended mainly on neural networks and machine learning to generate binders. However, the complexity of protein–protein interactions and the limitations of data-driven ...
Biotechnology
Jul 30, 2025
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31
Researchers at the National Institutes of Health (NIH) have developed an artificial intelligence (AI) agent powered by a large language model (LLM) that creates more accurate and informative descriptions of biological processes ...
Biotechnology
Jul 28, 2025
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31
In the same vein as weather forecast models that predict developing storms, researchers have now developed a method to predict the cell activity in tissues over time. The new software combines genomics technologies with computational ...
Cell & Microbiology
Jul 25, 2025
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65
A new artificial intelligence model can improve the process of drug and vaccine discovery by predicting how efficiently specific mRNA sequences will produce proteins, both generally and in various cell types.
Biotechnology
Jul 25, 2025
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84
An international joint research effort has created a new standard framework that simplifies and enhances the accuracy and efficiency of synthetic biology research. This framework is anticipated to serve as an international ...
Molecular & Computational biology
Jul 24, 2025
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21
EMBL-EBI scientists and collaborators at Heidelberg University have developed CORNETO, a new computational tool that uses machine learning to gain meaningful insights from complex biological data. Details have been published ...
Molecular & Computational biology
Jul 22, 2025
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24
Enzymes catalyze chemical reactions in organisms—without which life would not be possible. Leveraging AlphaFold2 artificial intelligence, researchers at Charité—Universitätsmedizin Berlin have now succeeded in analyzing the ...
Evolution
Jul 9, 2025
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25
A Ph.D. student in biomolecular engineering at the University of California, Santa Cruz, has built a software program designed to facilitate the kind of precision genome editing involved in the development of cutting-edge ...
Biotechnology
Jul 8, 2025
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43
A team of researchers has developed a method that could transform the field of protein engineering. The new approach, called AI-informed Constraints for protein Engineering (AiCE), enables rapid and efficient protein evolution ...
Biotechnology
Jul 8, 2025
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34
