Antibiosis is a biological process in which one organism produces specific metabolites that adversely affect the survival, growth, reproduction, or physiology of another organism, typically of a different species. It commonly involves secretion of antibiotics, toxins, or other secondary metabolites into the surrounding environment, leading to inhibitory or lethal effects on competitors, pathogens, or symbionts. Antibiosis plays a critical role in microbial ecology, plant–microbe and microbe–microbe interactions, and biological control of pests and diseases, and is mechanistically distinct from resource competition or predation because its primary mode of action is chemically mediated interference rather than direct consumption or simple nutrient depletion.
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