Search results for dna gyrase

Evolution Dec 18, 2018

Looking for LUCA, the last universal common ancestor

Around 4 billion years ago there lived a microbe called LUCA: the Last Universal Common Ancestor. There is evidence that it could have lived a somewhat 'alien' lifestyle, hidden away deep underground in iron-sulfur rich hydrothermal ...

Biochemistry Nov 22, 2018

DNA with a twist: Discovery could further antibiotic drug development

Scientists reveal how a 'molecular machine' in bacterial cells prevents fatal DNA twisting, which could be crucial in the development of new antibiotic treatments.

Cell & Microbiology Oct 1, 2018

Ciprofloxacin has dramatic effects on the mitochondrial genome—antibiotics should be used cautiously

Antibiotics have saved many lives by rescuing patients with bacterial or fungal infections, but these valuable drugs also have a dark side. As with most clinical drugs, many antibiotics can also have undesired effects on ...

Biochemistry Jun 1, 2017

Scientists discover a new way to target drug-resistant bacteria

John Innes Centre scientists are among an international team who have discovered a new class of compounds that target bacteria in a unique way.

Biochemistry Feb 11, 2016

New target found in search for new, more effective herbicide

Scientists at the John Innes Centre have discovered a new target in plants for the development of new herbicides for use by farmers and gardeners.

Biochemistry Jan 18, 2016

Scientists take steps to make weak TB drugs strong again

Biophysicists have discovered why the bacteria that cause tuberculosis (TB) are naturally somewhat resistant to antibiotics known as fluoroquinolones. Their findings, based on mapping the detailed three-dimensional structure ...

Cell & Microbiology Aug 20, 2015

FIC proteins send bacteria into hibernation

Bacteria do not cease to amaze us with their survival strategies. A research team from the University of Basel's Biozentrum has now discovered how bacteria enter a sleep mode using a so-called FIC toxin. In the current issue ...

Sep 3, 2008

Energy-saving bacteria resist antibiotics

Bacteria save energy by producing proteins that moonlight, having different roles at different times, which may also protect the microbes from being killed. The moonlighting activity of one enzyme from the tuberculosis bacterium ...

Nov 21, 2007

Direct evidence that bioclocks control chromosome coiling

There is a new twist on the question of how biological clocks work. In recent years, scientists have discovered that biological clocks help organize a dizzying array of biochemical processes in the body. Despite a number ...

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