By creating a powerful new gene regulation system called CRISPR-on, Whitehead Institute researchers now have the ability to increase the expression of multiple genes simultaneously and precisely manipulate each gene's expression ...
Biotechnology
Aug 27, 2013
0
0
In the classical view of evolution, species experience spontaneous genetic mutations that produce various novel traits—some helpful, some detrimental. Nature then selects for those most beneficial, passing them along to ...
Evolution
Dec 12, 2013
3
0
Nearly every cell in our body contains pairs of each of our chromosomes, and these pairs are identical in all but one case: that of our sex chromosomes. Males typically have one X and one Y sex chromosome, while females typically ...
Cell & Microbiology
Feb 9, 2023
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129
What do the painkillers morphine and codeine, the cancer chemotherapy drug vinblastine, the popular brain health supplement salidroside, and a plethora of other important medicines have in common? They are all produced in ...
Evolution
May 6, 2020
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306
More than 10 percent of our genome is made up of repetitive, seemingly nonsensical stretches of genetic material called satellite DNA that do not code for any proteins. In the past, some scientists have referred to this DNA ...
Evolution
Aug 23, 2021
1
611
Whitehead Institute researchers have conducted the first genome-wide screen in Apicomplexa, a phylum of single-celled parasites that cause malaria, babesiosis, cryptosporidiosis, and toxoplasmosis. The screen sheds light ...
Biotechnology
Sep 1, 2016
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540
Whitehead Institute researchers have used the gene regulation system CRISPR/Cas to engineer mouse genomes containing reporter and conditional alleles in one step. Animals containing such sophisticated engineered alleles can ...
Cell & Microbiology
Aug 29, 2013
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0
A family of nutrient-sensing enzymes, dubbed Rag GTPases, modulates the activity of the mTORC1 protein complex, whose inhibition is essential for autophagy and survival in newborn mammals. One enzyme, RagA, has been found ...
Cell & Microbiology
Dec 23, 2012
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0
The so-called central dogma of molecular biology—that DNA makes RNA which makes protein—has long provided a simplified explanation for how genetic information is deciphered and translated in living organisms.
Cell & Microbiology
Sep 15, 2014
9
0
A team of Whitehead Institute scientists has discovered that during division, stem cells distinguish between old and young mitochondria and allocate them disproportionately between daughter cells. As a result, the daughter ...
Cell & Microbiology
Apr 2, 2015
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201
