A molecular atlas of skin cells

Skin is protective against physical injury, radiation and microbes, and at the same time, produces hair and facilitates perspiration. Details of how skin cells manage such disparate tasks have so far remained elusive. Now, ...

Breakthrough in sex-chromosome regulation

Researchers at Karolinska Institutet in Sweden have uncovered a chromosome-wide mechanism that keeps the gene expression of sex chromosomes in balance in our cells. The findings shed light on molecular reasons for early miscarriage ...

New CRISPR-Cas9 variant may boost precision in gene editing

Researchers have developed a new variant of the gene editing technique CRISPR-Cas9 that has the potential to increase precision during gene therapy in humans. The new variant reduced unintended changes in DNA compared to ...

New method for imaging biological molecules

Researchers at Karolinska Institutet in Sweden, together with colleagues from Aalto University in Finland, have developed a new method for creating images of molecules in cells or tissue samples. The method is based on the ...

Molecular puzzle reveals unknown stages of fetal development

By applying gene analysis to individual cells from early mouse embryos, researchers at Karolinska Institutet in Sweden have discovered previously unknown cellular stages of fetal development from fertilised egg to living ...

New possible target for treating major common diseases

There is a large, untapped potential for developing drugs against cancer, fibrosis and cardiovascular diseases by targeting a family of receptors known as Frizzleds, researchers at Karolinska Institutet in Sweden believe. ...

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