New trick found for how cells stay organized

Organization is key to an efficient workplace, and cells are no exception to this rule. New evidence from Johns Hopkins researchers suggests that, in addition to membranes, cells have another way to keep their contents and ...

Locking mechanism found for 'scissors' that cut DNA

Researchers at Johns Hopkins have discovered what keeps an enzyme from becoming overzealous in its clipping of DNA. Since controlled clipping is required for the production of specialized immune system proteins, an understanding ...

Scientists map mouse genome's 'mission control centers'

When the mouse and human genomes were catalogued more than 10 years ago, an international team of researchers set out to understand and compare the "mission control centers" found throughout the large stretches of DNA flanking ...

How cells know which way to go

Amoebas aren't the only cells that crawl: Movement is crucial to development, wound healing and immune response in animals, not to mention cancer metastasis. In two new studies from Johns Hopkins, researchers answer long-standing ...

Some anti-inflammatory drugs affect more than their targets

Researchers have discovered that three commonly used nonsteroidal anti-inflammatory drugs, or NSAIDs, alter the activity of enzymes within cell membranes. Their finding suggests that, if taken at higher-than-approved doses ...

Engineering long-lasting joint lubrication by mimicking nature

By finding a way to bind a slippery molecule naturally found in the fluid that surrounds healthy joints, Johns Hopkins researchers have engineered surfaces that have the potential to deliver long-lasting lubrication at specific ...

Molecular 'eat now' signal makes cells devour dying neighbors

A team of researchers has devised a Pac-Man-style power pellet that gets normally mild-mannered cells to gobble up their undesirable neighbors. The development may point the way to therapies that enlist patients' own cells ...

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