New treatment yields complete regression of a human cancer in mice

Apr 23, 2007

A simple modification in an anti-cancer treatment currently in clinical trials substantially improves the drug’s effectiveness and reduces side effects in experiments with laboratory mice, researchers are reporting in an article scheduled for the May 16 edition of ACS’ Bioconjugate Chemistry. Enzon Pharmaceuticals’ David Filpula and colleagues at the National Cancer Institute worked on SS1P, a so-called immunotoxin that targets and destroys cells producing the surface protein mesothelin.

Ovarian, pancreatic and malignant mesothelioma cells all produce abnormally large amounts of mesothelin and thus are targets for SS1P. In the new study, researchers modified SS1P with PEGylation, which involves attaching chains of polyethylene glycol (also known as PEG) to the molecule. PEGylation is a well-established process that is used in at least six protein-based pharmaceutical products currently on the market.

PEGylated SS1Ps had fewer side effects and were more effective in mice bearing human tumors than standard SS1P, the report states. A single dose of the modified SS1P resulted in complete regression of the mouse tumors, the first time that such an effect had been observed, the researchers said. PEGylation of SS1P and other immunotoxins may hold promise for use in cancer patients, as well, they added.

Source: ACS

Explore further: New method allows for greater variation in band gap tunability

add to favorites email to friend print save as pdf

Related Stories

Galaxy dust findings confound view of early Universe

3 hours ago

What was the Universe like at the beginning of time? How did the Universe come to be the way it is today?—big questions and huge attention paid when scientists attempt answers. So was the early-universe ...

Recommended for you

Pinholes are pitfalls for high performance solar cells

Jan 30, 2015

The most popular next-generation solar cells under development may have a problem – the top layer is full of tiny pinholes, researchers at the Okinawa Institute of Science and Technology Graduate University ...

Chemistry in a trillionth of a second

Jan 30, 2015

Chemists at the University of Bristol, in collaboration with colleagues at the Central Laser Facility at the Rutherford Appleton Laboratory (RAL) and Heriot-Watt University (HWU), can now follow chemical ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.