Humans, flies smell alike, neurobiologists find

Mar 26, 2007

The nose knows – whether it’s on a fruit fly or a human. And while it would seem that how a fruit fly judges odors should differ from how a human smells, new research from Rockefeller University finds that at the neurobiological level, the two organisms have more in common than one might expect.

While it is very easy to ask a person about an odor – how intense it is, what it is similar to – it is slightly harder with an insect. “It is not known in much detail how these insects respond behaviorally to odors,” says Andreas Keller, first author of the paper and a postdoc in the laboratory of Chemers Family Associate Professor Leslie Vosshall. Keller designed experiments to look at exactly how a single fly would behave when exposed to different odors. He and Vosshall found that both flies and humans judge odor intensity the same way, but differ in their judgment of quality.

In flies, as in humans, the olfactory system is composed of nerve cells, each of which expresses an odorant receptor. Each receptor recognizes a small set of odors and it is the combination of the nerves that respond to each odor that generates our, or the fruit fly’s, reaction to the smell. Each animal has a different number of these odorant receptors – there are 1,200 in mice, 400 in humans and 61 in fruit flies. Vosshall and Keller wanted to know how it is that humans and fruit flies can coexist and develop such very different numbers of odorant receptors.

“It is not well understood how the varying numbers of odorant receptors impact odor perception across the different species,” says Vosshall. “Our research found that while determining the intensity of an odor is conserved in humans and flies, odors that smell similar to a human do not necessarily smell similar to a fly.” There may be fundamental variations in the properties of the fly and human olfactory systems that cause the difference.

Vosshall and Keller also saw that the contribution of a specific odorant receptor could not be predicted based on its physiological function. When they genetically removed single odorant receptors from a fly they could not predict how that would change the fly’s behavior. “It may be that by removing just one receptor it changes the whole olfactory system and produces an entirely new odor precept,” says Vosshall. “Investigating how a fruit fly experiences odors can provide us with clues to our own subjective experiences of smell.”

Citation: Proceedings of the National Academy of Sciences Online: March 19, 2007

Source: Rockefeller University

Explore further: Researchers identify new mechanism to aid cells under stress

add to favorites email to friend print save as pdf

Related Stories

Environmentally friendly coating for aircraft furniture

Jan 09, 2015

A new coating protects business jet interiors against fire. Not only is the agent more environmentally friendly than before; it can also be applied more quickly. Empa is thus helping the Swiss company Jet ...

In the face of stress, flies unite

Dec 30, 2014

Flies exposed to a stress signal when in a group adopt a more effective response than isolated insects, found researchers at UNIL and EPFL. These typically solitary dipterans interact to generate a coherent ...

Toxic fruits hold the key to reproductive success

Dec 09, 2014

In the course of evolution, animals have become adapted to certain food sources, sometimes even to plants or to fruits that are actually toxic. The driving forces behind such adaptive mechanisms are often ...

The midge that eats more kale

Nov 13, 2014

Three years ago, Tony Lehouillier began to worry about some of his purple kale. "It was just weird looking," he says, cupping his hands around a tall stalk on his farm near Johnson, Vt. "Then the top would ...

Dead fish in Rio Olympic bay baffle scientists

Nov 08, 2014

Thousands of dead fish have begun mysteriously washing up in the polluted Rio bay that will host sailing events at the 2016 Olympics—and experts are at a loss to explain why.

Recommended for you

Researchers identify new mechanism to aid cells under stress

9 hours ago

A team of biologists from NYU and Harvard has identified new details in a cellular mechanism that serves as a defense against stress. The findings potentially offer insights into tumor progression and neurodegenerative diseases, ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.