Mouse to man: The story of chromosomes

Apr 19, 2006

U.S. scientists say sequencing human chromosome 17 and mouse chromosome 11 has offered unique insights into the evolution of the genome of higher mammals.

A Baylor College of Medicine researcher who participated in the effort says the work represents the first time a mouse chromosome has been completely sequenced and annotated.

That feat, says Professor James Lupski, presents scientists with the opportunity to intensively examine the similarities and differences in the DNA sequence of human and mouse.

Lupski was brought into the work while on sabbatical at the Wellcome Trust Sanger Institute in Cambridge, England. The Sanger Institute, the Broad Institute of MIT, and Harvard University were the primary institutions involved in the sequencing effort.

Lupski says the study presents a clearer picture of how genome changes through evolution.

"As we go up the mammalian line, and particularly in primate, it is obvious that rearrangement in the genome is the predominant force in the evolution of genomes," said Lupski. "Perhaps one way to evolve faster is not by making changes (the chemicals that make up DNA), but by changing chunks of genome."

The study appears in the journal Nature.

Copyright 2006 by United Press International

Explore further: Study finds female entrepreneurs are discounted because of their gender

add to favorites email to friend print save as pdf

Related Stories

Spacewalking astronauts finish extensive, trick cable job

13 hours ago

(AP)—Spacewalking astronauts successfully completed a three-day cable job outside the International Space Station on Sunday, routing several-hundred feet of power and data lines for new crew capsules commissioned ...

IOC defends Rio legacy amid green protests

15 hours ago

Ecological protests on Saturday dogged the final day of an International Olympic Committee executive board meeting in Rio as green campaigners slated the choice of a nature reserve to hold the golf event ...

Recommended for you

Professor analyzes role of trade sanctions against Iran

1 hour ago

Israeli Prime Minister Benjamin Netanyahu addressed Congress on Tuesday as about 50 Democratic lawmakers threatened to boycott the address, offering the latest and one of the most clear microcosms of the debate about Iran's ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.