Mouse to man: The story of chromosomes

Apr 19, 2006

U.S. scientists say sequencing human chromosome 17 and mouse chromosome 11 has offered unique insights into the evolution of the genome of higher mammals.

A Baylor College of Medicine researcher who participated in the effort says the work represents the first time a mouse chromosome has been completely sequenced and annotated.

That feat, says Professor James Lupski, presents scientists with the opportunity to intensively examine the similarities and differences in the DNA sequence of human and mouse.

Lupski was brought into the work while on sabbatical at the Wellcome Trust Sanger Institute in Cambridge, England. The Sanger Institute, the Broad Institute of MIT, and Harvard University were the primary institutions involved in the sequencing effort.

Lupski says the study presents a clearer picture of how genome changes through evolution.

"As we go up the mammalian line, and particularly in primate, it is obvious that rearrangement in the genome is the predominant force in the evolution of genomes," said Lupski. "Perhaps one way to evolve faster is not by making changes (the chemicals that make up DNA), but by changing chunks of genome."

The study appears in the journal Nature.

Copyright 2006 by United Press International

Explore further: No silver bullet: Study identifies risk factors of youth charged with murder

add to favorites email to friend print save as pdf

Related Stories

Special chromosomal structures control key genes

Oct 09, 2014

Within almost every human cell is a nucleus six microns in diameter—about one 300th of a human hair's width—that is filled with roughly three meters of DNA. As the instructions for all cell processes, the DNA must be ...

Recommended for you

Data indicate there is no immigration crisis

13 hours ago

Is there an "immigration crisis" on the U.S.-Mexico border? Not according to an examination of historical immigration data, according to a new paper from Rice University's Baker Institute for Public Policy.

The unexpected benefits of adjustable rate mortgages

14 hours ago

Using loan level data matched to consumer credit records, researchers have been able to determine that a reduction in mortgage payments of as little as $150 a month spurred a reduction in mortgage defaults and an increase ...

User comments : 0